Classification, characteristics, harmless treatment and safety assessment of antibiotic pharmaceutical wastewater (APWW): A comprehensive review.

Abstract

The issues related to the spread of antibiotics and antibiotic resistance genes (ARGs) have garnered significant attention from researchers and governments. The production of antibiotics can lead to the emission of high-concentration pharmaceutical wastewater, which contains antibiotic residues and various other pollutants. This review compiles the classification and characteristics of antibiotic pharmaceutical wastewater (APWW), offers an overview of the development, advantages, and disadvantages of diverse harmless treatment processes, and presents a strategy for selecting appropriate treatment approaches. Biological treatment remains the predominant approach for treating APWW. In addition, several alternative methods can be employed to address the challenges associated with APWW treatment. On the other hand, the present safety assessment of the effluent resulting from APWW treatment is inadequate, necessitating more comprehensive research in this domain. It is recommended that researches in this area consider the issue of toxicity and antibiotic resistance as well. The PNEC^R model (similar to ecotoxicological PNECs but used to specifically refer to endpoints related to antimicrobial resistance) (Murray et al., 2024) is an emerging tool used for evaluating the antimicrobial resistance (AMR) issue. This model is, characterized by its simplicity and effectiveness, is a promising tool for assessing the safety of treated APWW.