Experimental Investigation of the Effect of Polydioxanone Plate and Platelet-Rich Plasma on Cartilage Regeneration.

Ahmet Halit Aydin, Ercan Kaya, Deniz Arik, Funda Canaz, Mehmet Ozgur Pinarbasli, Melek Kezban Gurbuz, Hamdi Cakli, Cemal Cingi
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Abstract

Objectives: This study aimed to investigate the effectiveness of polydioxanone (PDS) plate and platelet-rich plasma (PRP) on the regeneration of cartilage grafts, which are frequently used in nasal and septal surgery. Methods: Fifteen white New Zealand Albino-type female rabbits were used in the study. Our study was carried out on 4 different applications on each animal: cartilage only, cartilage+PRP, cartilage+PDS plate, and cartilage+PRP+PDS plate, and in 3 different periods: the first month, the second month, and the third month. Results: A significant difference was obtained between the groups using cartilage+PRP and cartilage+PRP+PDS only in the first month. When both application types were compared, a statistically significant decrease was found in the histopathological cartilage viability score after PDS use. In examining peripheral chondrocyte proliferation, a statistically significant difference was found only in the third-month comparison. When the group using only cartilage was compared with the group using cartilage+PDS, it was determined that peripheral chondrocyte proliferation was significantly reduced at the end of the third month with PDS. In evaluating fibrosis and foreign body reaction, a statistically significant increase was detected using a PDS plate. In histopathological cartilage viability score statistical analysis, a significant difference was obtained between the groups using cartilage+PRP and cartilage+PRP+PDS only in the first month. Degeneration in the cartilage structure was observed macroscopically in the specimens where the PDS plate was used. Shape change and cartilage deformation were observed in the PDS plate specimens. Conclusions: When the results were examined, this observation coincided with the statistically significant increase in foreign body reaction and fibrosis in the PDS plate groups. However, these results contradicted our hypothesis before the study and the information in the literature. Our results will help provide preliminary information and guidance for future studies and offer a different perspective.

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聚二氧酮板和富血小板血浆对软骨再生影响的实验研究
研究目的本研究旨在探讨聚二氧酮(PDS)板和富血小板血浆(PRP)对鼻腔和鼻中隔手术中常用的软骨移植的再生效果。方法:研究使用了 15 只白色新西兰白化型雌兔。我们的研究对每只动物进行了 4 种不同的应用:仅软骨、软骨+PRP、软骨+PDS 板和软骨+PRP+PDS 板,并分 3 个不同时期进行:第一个月、第二个月和第三个月。结果使用软骨+PRP 和软骨+PRP+PDS 的组别仅在第一个月有明显差异。在对两种应用类型进行比较后发现,使用 PDS 后,组织病理学软骨活力评分出现了统计学意义上的显著下降。在检查外周软骨细胞增殖时,只有在第三个月的比较中才发现有统计学意义的差异。将只使用软骨的组与使用软骨+PDS的组进行比较,结果发现,在使用PDS的第三个月末,外周软骨细胞增殖明显减少。在评估纤维化和异物反应时,发现使用 PDS 板时,纤维化和异物反应在统计学上明显增加。在组织病理学软骨活力评分统计分析中,使用软骨+PRP 和软骨+PRP+PDS 的组间仅在第一个月有显著差异。在使用 PDS 板的标本中,宏观观察到软骨结构退化。在使用 PDS 板的试样中观察到了形状变化和软骨变形。结论:在对结果进行检查时,这一观察结果与 PDS 骨板组异物反应和纤维化在统计学上的显著增加不谋而合。然而,这些结果与我们在研究前的假设和文献信息相矛盾。我们的结果将有助于为今后的研究提供初步信息和指导,并提供一个不同的视角。
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