Venous thromboembolism during pregnancy and postpartum period: an updated review.

Sanaullah Mojaddedi, Javairia Jamil, Andrew Abraham, Dawood Jamil, Hend Mansoor, Islam Y Elgendy
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Abstract

Venous thromboembolism (VTE) is a leading cause of maternal mortality. The risk of VTE in pregnant and postpartum women is ~ five times higher compared with non-pregnant women. There is a physiological tendency to a hypercoagulable state, from conception to the postpartum period. Several non-obstetric risk factors independently increase the risk of VTE. Since most signs and symptoms of VTE might mimic those of a normal pregnancy, a high index of suspicion is warranted to establish the diagnosis. D-dimer, ultrasonography and computed tomography pulmonary angiography are the primary tools for VTE diagnosis. Management mainly revolves around systemic anticoagulation with heparin. Advanced therapy options exist, but these can be considered for selected high-risk cases.

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孕期和产后静脉血栓栓塞:最新综述。
静脉血栓栓塞症(VTE)是孕产妇死亡的主要原因。孕妇和产后妇女发生 VTE 的风险是非孕妇的 5 倍。从受孕到产后期间,孕妇会出现高凝状态的生理倾向。一些非产科风险因素会独立增加 VTE 风险。由于大多数 VTE 的症状和体征可能与正常妊娠相似,因此需要高度怀疑才能确诊。D-二聚体、超声波和计算机断层扫描肺血管造影是诊断 VTE 的主要工具。治疗主要围绕使用肝素进行全身抗凝。虽然存在先进的治疗方案,但这些方案只适用于特定的高风险病例。
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