Front Cover: Fluorocarbon-DNA Conjugates for Enhanced Cellular Delivery: Formation of a Densely Packed DNA Nano-Assembly (ChemBioChem 19/2024)

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2024-10-01 DOI:10.1002/cbic.202481901
Minako Narita, Dr. Ai Kohata, Taiichi Kageyama, Honoka Watanabe, Dr. Kohsuke Aikawa, Prof. Dr. Daisuke Kawaguchi, Dr. Kunihiko Morihiro, Prof. Dr. Akimitsu Okamoto, Dr. Takashi Okazoe
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Abstract

Several RF-DNA conjugates are synthesized, and the relationship between the uptake efficiency and the physicochemical properties is systematically investigated. RF-DNA conjugates carrying two C8F17 groups at the terminus of a DNA strand form a nano-assembly with the highest DNA content, leading to the greatest cellular uptake via scavenger receptors. More details can be found in article 10.1002/cbic.202400436 by Ai Kohata, Kohsuke Aikawa, and co-workers.

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封面:用于增强细胞递送的氟碳-DNA 结合物:形成密集包装的 DNA 纳米组装(ChemBioChem 19/2024)
我们合成了几种 RF-DNA 共轭物,并系统地研究了吸收效率与理化性质之间的关系。在 DNA 链的末端带有两个 C8F17 基团的 RF-DNA 共轭物形成了 DNA 含量最高的纳米组装体,通过清道夫受体被细胞吸收的可能性最大。更多详情请见 Ai Kohata、Kohsuke Aikawa 及合作者的文章 10.1002/cbic.202400436。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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