Per and poly-fluoroalkyl substances and respiratory health in an Inuit community.

IF 5.3 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Environmental Health Pub Date : 2024-10-12 DOI:10.1186/s12940-024-01126-7

Amira Aker, Yohann Courtemanche, Pierre Ayotte, Philippe Robert, Éric Gaudreau, Mélanie Lemire

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Abstract

Background: Concentrations of plasma per and poly-fluoroalkyl substances (PFAS) are elevated in the Inuit population of Nunavik and may be causing adverse health effects. Respiratory health outcomes have been associated with PFAS, but have not been explored in Inuit communities. The aim of the study was to examine the association between PFAS and respiratory health outcomes, and the moderating role of nutritional biomarkers.

Methods: We included up to 1298 participants of the Qanuilirpitaa? 2017 survey aged 16-80 years. Generalized regression models were used to estimate the associations between six individual PFAS congeners and four self-reported symptoms, four spirometry measures, and physician-diagnosed asthma. Outcomes associated with PFAS from single chemical models were further explored using Bayesian Kernel Machine Regression (BKMR). The modifying effect of n-3 PUFA in red blood cell quartiles and vitamin D deficiency were examined on the associations between PFAS and respiratory outcomes.

Results: PFNA and PFOS were associated with asthma (odds ratio (OR) 1.61, 95% confidence interval (CI) 1.12, 2.32; OR 1.45 95% CI 1.04, 2.03). PFOA, PFNA, PFDA and PFHxS were associated with a decrease in the ratio between the forced expiratory volume in the first second and forced vital capacity (FEV1/FVC). No associations were observed with self-reported respiratory symptoms. No associations were observed between a PFAS mixture and asthma. Some associations were modified by nutritional factors, namely, stronger associations between PFOA and PFHxS and asthma with lower n-3 PUFA levels and stronger associations between PFDA, PFUnDA and PFOS and FEV1/FVC with vitamin D deficiency.

Conclusion: These findings add to the growing literature on the impacts of PFAS on respiratory health, and the importance of their global regulation. Associations were modified by nutritional factors pointing to the nutritional value of traditional Inuit foods.

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因纽特人社区中的全氟和多氟烷基物质与呼吸系统健康。

背景：努纳维克因纽特人血浆中的全氟烷基和多氟烷基物质（PFAS）浓度升高，可能会对健康造成不良影响。呼吸系统的健康状况与全氟烷基磺酸盐有关，但尚未在因纽特人社区进行过研究。本研究旨在探讨全氟辛烷磺酸与呼吸系统健康后果之间的关系，以及营养生物标志物的调节作用：我们纳入了多达 1298 名年龄在 16-80 岁之间的 Qanuilirirpitaa?采用广义回归模型估算了六种全氟辛烷磺酸同系物与四种自我报告症状、四种肺活量测量和医生诊断的哮喘之间的关联。使用贝叶斯核机器回归（BKMR）进一步探讨了单一化学模型中与 PFAS 相关的结果。还研究了红细胞四分位数中的 n-3 PUFA 和维生素 D 缺乏对 PFAS 与呼吸系统结果之间关系的调节作用：结果：PFNA 和 PFOS 与哮喘有关（几率比（OR）1.61，95% 置信区间（CI）1.12，2.32；OR 1.45，95% 置信区间（CI）1.04，2.03）。PFOA、PFNA、PFDA 和 PFHxS 与第一秒用力呼气量和用力肺活量（FEV1/FVC）之比下降有关。未观察到与自我报告的呼吸道症状有关。未发现全氟辛烷磺酸混合物与哮喘之间存在关联。一些关联因营养因素而改变，即 PFOA 和 PFHxS 与 n-3 PUFA 水平较低的哮喘之间的关联较强，PFDA、PFUnDA 和 PFOS 与维生素 D 缺乏的 FEV1/FVC 之间的关联较强：这些发现丰富了有关全氟辛烷磺酸对呼吸系统健康的影响以及对其进行全球监管的重要性的文献。营养因素改变了相关性，这表明传统因纽特食品具有营养价值。

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来源期刊

Environmental Health 环境科学-公共卫生、环境卫生与职业卫生

CiteScore

10.10

自引率

1.70%

发文量

115

审稿时长

3.0 months

期刊介绍： Environmental Health publishes manuscripts on all aspects of environmental and occupational medicine and related studies in toxicology and epidemiology. Environmental Health is aimed at scientists and practitioners in all areas of environmental science where human health and well-being are involved, either directly or indirectly. Environmental Health is a public health journal serving the public health community and scientists working on matters of public health interest and importance pertaining to the environment.