Unique Gut Microbiome and Metabolic Profiles in Chinese Workers Exposed to Dust: Insights From a Case-Control Study.

Xiaojun Qian, Ying Liu, Xue Wei, Xiaorong Chen, Guangsheng Rong, Xinxin Hu
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Abstract

Objectives: This study aimed to identify distinct gut microbiome and serum metabolic features in workers exposed to dust compared to healthy controls.

Methods: A case-control study was conducted with dust-exposed workers without silicosis and age-matched healthy controls. Gut microbiome composition was analyzed using 16S rRNA sequencing, and serum and fecal metabolomic profiles were assessed by LC-MS.

Results: Dust-exposed workers showed higher levels of Blautia and Trichoderma and lower levels of Anaplasma , Aspergillus , Plasmodiophoromycetes, and Escherichia coli-Shigella . Metabolites such as indole-3-acetate and gentamicin C1a were downregulated, while adenine, 2-phenylacetamide, and 4-pyridoxic acid were upregulated.

Conclusions: Blautia spp. were linked to altered metabolites in dust-exposed workers, suggesting microbiome-metabolite interactions that may affect silicosis progression. However, the small sample size and cross-sectional design limit generalizability, and further longitudinal studies are needed.

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暴露于粉尘的中国工人独特的肠道微生物组和代谢特征:一项病例对照研究的启示。
目的:本研究旨在确定与健康对照组相比,接触粉尘的工人的肠道微生物组和血清代谢特征:本研究旨在确定与健康对照组相比,暴露于粉尘的工人的肠道微生物组和血清代谢特征:方法:对未患矽肺病的接触粉尘工人和年龄匹配的健康对照组进行病例对照研究。采用 16S rRNA 测序分析了肠道微生物组的组成,并通过 LC-MS 评估了血清和粪便的代谢组学特征:结果表明:接触粉尘的工人体内布劳菌和毛霉的含量较高,而支原体、曲霉菌、浆霉菌和大肠埃希氏菌的含量较低。吲哚-3-乙酸酯和庆大霉素 C1a 等代谢物含量下降,而腺嘌呤、2-苯乙酰胺和 4-吡哆酸含量上升:结论:布劳氏菌与暴露于粉尘的工人体内代谢物的改变有关,这表明微生物与代谢物之间的相互作用可能会影响矽肺病的发展。然而,样本量小和横断面设计限制了推广性,需要进一步的纵向研究。
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