{"title":"Unique Gut Microbiome and Metabolic Profiles in Chinese Workers Exposed to Dust: Insights From a Case-Control Study.","authors":"Xiaojun Qian, Ying Liu, Xue Wei, Xiaorong Chen, Guangsheng Rong, Xinxin Hu","doi":"10.1097/JOM.0000000000003243","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to identify distinct gut microbiome and serum metabolic features in workers exposed to dust compared to healthy controls.</p><p><strong>Methods: </strong>A case-control study was conducted with dust-exposed workers without silicosis and age-matched healthy controls. Gut microbiome composition was analyzed using 16S rRNA sequencing, and serum and fecal metabolomic profiles were assessed by LC-MS.</p><p><strong>Results: </strong>Dust-exposed workers showed higher levels of Blautia and Trichoderma and lower levels of Anaplasma , Aspergillus , Plasmodiophoromycetes, and Escherichia coli-Shigella . Metabolites such as indole-3-acetate and gentamicin C1a were downregulated, while adenine, 2-phenylacetamide, and 4-pyridoxic acid were upregulated.</p><p><strong>Conclusions: </strong>Blautia spp. were linked to altered metabolites in dust-exposed workers, suggesting microbiome-metabolite interactions that may affect silicosis progression. However, the small sample size and cross-sectional design limit generalizability, and further longitudinal studies are needed.</p>","PeriodicalId":94100,"journal":{"name":"Journal of occupational and environmental medicine","volume":" ","pages":"1072-1082"},"PeriodicalIF":0.0000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of occupational and environmental medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1097/JOM.0000000000003243","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/10/10 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Objectives: This study aimed to identify distinct gut microbiome and serum metabolic features in workers exposed to dust compared to healthy controls.
Methods: A case-control study was conducted with dust-exposed workers without silicosis and age-matched healthy controls. Gut microbiome composition was analyzed using 16S rRNA sequencing, and serum and fecal metabolomic profiles were assessed by LC-MS.
Results: Dust-exposed workers showed higher levels of Blautia and Trichoderma and lower levels of Anaplasma , Aspergillus , Plasmodiophoromycetes, and Escherichia coli-Shigella . Metabolites such as indole-3-acetate and gentamicin C1a were downregulated, while adenine, 2-phenylacetamide, and 4-pyridoxic acid were upregulated.
Conclusions: Blautia spp. were linked to altered metabolites in dust-exposed workers, suggesting microbiome-metabolite interactions that may affect silicosis progression. However, the small sample size and cross-sectional design limit generalizability, and further longitudinal studies are needed.