Review of the current ongoing clinical trials exploring the possible anti-anxiety effects of cannabidiol.

IF 4.1 Q1 PHARMACOLOGY & PHARMACY Journal of cannabis research Pub Date : 2024-10-12 DOI:10.1186/s42238-024-00250-y
Rhenu Bhuller, Walter K Schlage, Julia Hoeng
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Abstract

Background: Anxiety disorders (ADs) are a complex group of mental disorders and majorly contribute to the global health-related burden. Symptoms and clinical management differ widely depending on the specific diagnosis. There is a need for new, more effective pharmacological treatments for these patients as many patients do not respond to treatment and treatment is not available for several types of AD. The increased interest in the potential effects of cannabidiol (CBD) on symptoms of AD has led to several preclinical and clinical studies that suggest that CBD may be effective in some patients with AD. However, it remains unclear whether and how CBD can be used in the clinical management of ADs due to a lack of sufficiently robust clinical evidence.

Comparative evaluation: This narrative review provides a critical analysis of the current state of the art for ADs and summarizes six recently completed and 22 currently ongoing clinical trials investigating the effects of CBD on ADs or anxiety. The aim was to examine whether the ongoing trials are likely to provide the necessary solid evidence, or whether new studies with more robust design parameters can help to overcome the prevailing lack of solid clinical data for this CBD indication. Most of the trials reviewed are considered exploratory and do not focus on specific types of clinical anxiety or ADs as the primary condition studied. Participant numbers, CBD dose, treatment duration, and CBD formulation vary widely among the studies, and all but two are single-center studies.

Conclusion: For an effective clinical management of ADs using CBD, there is a need for sufficiently powered and appropriately designed clinical trials (RCT, multicenter, defined doses and exposure monitoring, robust primary outcomes) investigating the effect of CBD in specific ADs, such as social anxiety disorder and panic disorder, or in post-traumatic stress disorder.

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回顾目前正在进行的探索大麻二酚可能抗焦虑作用的临床试验。
背景:焦虑症(ADs)是一类复杂的精神障碍,是全球健康相关负担的主要来源。症状和临床治疗因具体诊断而大不相同。由于许多患者对治疗没有反应,而且有几种类型的焦虑症没有治疗方法,因此需要为这些患者提供新的、更有效的药物治疗。人们越来越关注大麻二酚(CBD)对注意力缺失症症状的潜在影响,一些临床前和临床研究表明,大麻二酚可能对一些注意力缺失症患者有效。然而,由于缺乏足够有力的临床证据,大麻二酚是否以及如何用于AD的临床治疗仍不清楚:这篇叙述性综述对目前治疗注意力缺失症的技术水平进行了批判性分析,并总结了最近完成的 6 项临床试验和目前正在进行的 22 项临床试验,这些临床试验都在研究 CBD 对注意力缺失症或焦虑症的影响。目的是研究正在进行的试验是否有可能提供必要的确凿证据,或者设计参数更可靠的新研究是否有助于克服目前CBD适应症缺乏确凿临床数据的问题。所审查的大多数试验都被认为是探索性的,并不以特定类型的临床焦虑或注意力缺失症为主要研究对象。各项研究的参与者人数、CBD剂量、治疗持续时间和CBD配方差异很大,除两项研究外,其余均为单中心研究:结论:要想利用 CBD 对焦虑症进行有效的临床治疗,就需要进行有足够支持力、设计合理的临床试验(RCT、多中心、明确剂量和暴露监测、可靠的主要结果),研究 CBD 对特定焦虑症(如社交焦虑症和恐慌症)或创伤后应激障碍的影响。
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