Synthesis of Some Novel (E)-1,5-Dimethyl-2-phenyl-4-(((2-arylimidazo[1,2-a]pyridin-3-yl)-methylene)amino)-1,2-dihydro-3H-pyrazol-3-one Derivatives: Exploring Their Antimicrobial Activity

Abstract

Objective: The most comprehensive collection of imine was synthesized via a simple, efficient, economical, and rapid method via Schiff base formation. Methods: ((E)-1,5-dimethyl-2-phenyl-4-(((2-phenylimidazo[1,2-a]pyridine-3-yl)methylene)amino)-1,2-dihydro-3H-pyrazol-3-one and their derivatives are synthesized using 4-aminoantipyrine and some substituted 2-phenylimidazo[1,2-a]pyridine-3-carbaldehyde derivatives (SB01) to (SB10). Results and Discussion: The newly synthesized molecules were confirmed using various analytical techniques MS, FT-IR, ¹H, and ¹³C NMR spectrometric analyses. Newly synthesized imidazo[1,2-a]pyridine compounds undergo their biological evaluation with Gram-positive and Gram-negative bacteria as well as antifungal. Conclusions: (SB10), (SB07), (SB05), and (SB01) molecules show good, moderate, and excellent results against tested drugs.