Preparation and Characterization of Electrospun Polyvinylpyrrolidone Nanofiber Mat Containing Phillyrea Latifolia L. Herbal Extract and Evaluation of Antioxidant Mechanism

Abstract

Purpose

Fast-disintegrating dosage forms based on nanofibers hold promise as effective carriers for a diverse array of drugs. In this study, our objective was to evaluate the effect of polymer polyvinylpyrrolidone (PVP) concentration on the disintegration time and drug release behavior of fast dissolving mats containing P. latifolia leaf extract.

Methods

To accomplish this goal, we created fast-dissolving nanofiber mats using different concentrations of PVP (20% and 25% w/w). The characterization of the rapidly dissolving nanofiber mats encompassed aspects such as drug content, fiber diameter, morphology, disintegration time, drug release behavior, and interactions between the drug and excipients.

Results

The diameter of nanofibers increased with the increase in PVP concentration in the formulations. The dissolution rate of the PVPE-20 and PVPE-25 formulations showed a high release of antioxidants from both formulations. The results revealed that a significantly higher release of antioxidants was observed in the PVPE-25 formulation, displaying the highest initial burst release of approximately 70.9% within the first minute, and releasing the entire drug, about 87.5%, within the first 5 min. Stability tests showed that the formulations were not significantly affected by storage.

Conclusion

The preliminary results presented here as a proof-of-concept demonstration will illuminate future designs and applications of fast-dissolving mats incorporating P. latifolia leaf extract via the electrospinning method.

Graphical Abstract