{"title":"Enhancement of corrosion, biocompatibility and drug delivery properties of nitinol implants surface by Al-Zn-LDH nanohybrids","authors":"","doi":"10.1016/j.colsurfa.2024.135524","DOIUrl":null,"url":null,"abstract":"<div><div>This study investigates the enhancement of drug delivery and corrosion resistance by incorporating dexamethasone sodium phosphate into aluminum-zinc layered double hydroxide (LDH) coated nickel-titanium alloys. The nickel-titanium samples were fabricated from titanium and nickel powders using spark plasma sintering (SPS) and cold press sintering (CPS), followed by electrophoretic deposition of LDH nanoparticles. This composite construction aims to utilize the biocompatibility and mechanical properties of nickel-titanium, combined with the controlled drug release and corrosion resistance properties of LDH coatings. Structural and microstructural characterizations were performed using X-ray diffraction and scanning electron microscopy. The results indicated that SPS samples exhibited superior microstructural homogeneity and corrosion resistance compared to CPS samples. Dexamethasone sodium phosphate was successfully intercalated into the LDH layers, as evidenced by an increase in layer spacing from 7.14 Å to 20.130 Å. The LDH-coated nickel-titanium with intercalated dexamethasone sodium phosphate demonstrated a 5 % lower drug release rate and significantly improved corrosion resistance compared to uncoated samples. Cell adhesion studies confirmed good biocompatibility between cells and the coated surface. This composite material shows promise for enhanced performance in biomedical applications, particularly in drug delivery and corrosion resistance.</div></div>","PeriodicalId":278,"journal":{"name":"Colloids and Surfaces A: Physicochemical and Engineering Aspects","volume":null,"pages":null},"PeriodicalIF":4.9000,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Colloids and Surfaces A: Physicochemical and Engineering Aspects","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0927775724023884","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
引用次数: 0
Abstract
This study investigates the enhancement of drug delivery and corrosion resistance by incorporating dexamethasone sodium phosphate into aluminum-zinc layered double hydroxide (LDH) coated nickel-titanium alloys. The nickel-titanium samples were fabricated from titanium and nickel powders using spark plasma sintering (SPS) and cold press sintering (CPS), followed by electrophoretic deposition of LDH nanoparticles. This composite construction aims to utilize the biocompatibility and mechanical properties of nickel-titanium, combined with the controlled drug release and corrosion resistance properties of LDH coatings. Structural and microstructural characterizations were performed using X-ray diffraction and scanning electron microscopy. The results indicated that SPS samples exhibited superior microstructural homogeneity and corrosion resistance compared to CPS samples. Dexamethasone sodium phosphate was successfully intercalated into the LDH layers, as evidenced by an increase in layer spacing from 7.14 Å to 20.130 Å. The LDH-coated nickel-titanium with intercalated dexamethasone sodium phosphate demonstrated a 5 % lower drug release rate and significantly improved corrosion resistance compared to uncoated samples. Cell adhesion studies confirmed good biocompatibility between cells and the coated surface. This composite material shows promise for enhanced performance in biomedical applications, particularly in drug delivery and corrosion resistance.
期刊介绍:
Colloids and Surfaces A: Physicochemical and Engineering Aspects is an international journal devoted to the science underlying applications of colloids and interfacial phenomena.
The journal aims at publishing high quality research papers featuring new materials or new insights into the role of colloid and interface science in (for example) food, energy, minerals processing, pharmaceuticals or the environment.