Noor Nabilah Talik Sisin , Raizulnasuha Ab Rashid , Reduan Abdullah , Arifah Nazirah Abdullah , Norhayati Dollah , Merfat Algethami , Awatef S. Assran , Faizal Mohamed , Wan Nordiana Rahman
{"title":"A new insight on the effects of Schiff Base Iron (III) complexes in breast cancer cells for clinical radiotherapy","authors":"Noor Nabilah Talik Sisin , Raizulnasuha Ab Rashid , Reduan Abdullah , Arifah Nazirah Abdullah , Norhayati Dollah , Merfat Algethami , Awatef S. Assran , Faizal Mohamed , Wan Nordiana Rahman","doi":"10.1016/j.apradiso.2024.111546","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><div>Breast cancer is a significant global health concern, and researchers strive to enhance radiotherapy outcomes while minimizing the side effects. Schiff Base Iron (III) Complexes are one of the prospective elements that can be used as radiosensitizer or radioprotective agents in cancer radiotherapy. This study investigates the potential effects of Schiff base (ligand 2; L<sup>2</sup>) with Fe(III) in MCF-7 breast cancer cells under clinical radiotherapy treatment.</div></div><div><h3>Methods</h3><div>The effects of the Schiff Base Iron (III) Complexes were measured using clonogenic assay with MCF-7 breast cancer cells. The cells were irradiated with megavoltage 6 MV photon, 6 MeV electron and high dose rate (HDR) brachytherapy with <sup>192</sup>Ir source at different doses. Intercellular localization of Fe(III)-L<sup>2</sup> complexes and antioxidant activities were also investigated.</div></div><div><h3>Results</h3><div>The Fe(III)-L<sup>2</sup> complexes were observed to be internalized by cellular nuclei without any effects on the cells. Interestingly, the Fe(III)-L2 complexes indicate radioprotective effects which provide intriguing insight towards application of metal ions complexes as radioprotector in cancer radiotherapy. The Fe(III)-L2 complexes also exhibit scavenging activities of free radical which further proved the antioxidative properties and radioprotective effects.</div></div><div><h3>Conclusion</h3><div>The Fe(III)-L<sup>2</sup> complexes show the radioprotective effects and antioxidant properties in MCF-7 cells, particularly for HDR brachytherapy. The findings suggest potential applications of the Fe(III)-L<sup>2</sup> complexes as radioprotector agents in clinical radiotherapy.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"214 ","pages":"Article 111546"},"PeriodicalIF":1.6000,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Applied Radiation and Isotopes","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0969804324003749","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
引用次数: 0
Abstract
Purpose
Breast cancer is a significant global health concern, and researchers strive to enhance radiotherapy outcomes while minimizing the side effects. Schiff Base Iron (III) Complexes are one of the prospective elements that can be used as radiosensitizer or radioprotective agents in cancer radiotherapy. This study investigates the potential effects of Schiff base (ligand 2; L2) with Fe(III) in MCF-7 breast cancer cells under clinical radiotherapy treatment.
Methods
The effects of the Schiff Base Iron (III) Complexes were measured using clonogenic assay with MCF-7 breast cancer cells. The cells were irradiated with megavoltage 6 MV photon, 6 MeV electron and high dose rate (HDR) brachytherapy with 192Ir source at different doses. Intercellular localization of Fe(III)-L2 complexes and antioxidant activities were also investigated.
Results
The Fe(III)-L2 complexes were observed to be internalized by cellular nuclei without any effects on the cells. Interestingly, the Fe(III)-L2 complexes indicate radioprotective effects which provide intriguing insight towards application of metal ions complexes as radioprotector in cancer radiotherapy. The Fe(III)-L2 complexes also exhibit scavenging activities of free radical which further proved the antioxidative properties and radioprotective effects.
Conclusion
The Fe(III)-L2 complexes show the radioprotective effects and antioxidant properties in MCF-7 cells, particularly for HDR brachytherapy. The findings suggest potential applications of the Fe(III)-L2 complexes as radioprotector agents in clinical radiotherapy.
期刊介绍：
Applied Radiation and Isotopes provides a high quality medium for the publication of substantial, original and scientific and technological papers on the development and peaceful application of nuclear, radiation and radionuclide techniques in chemistry, physics, biochemistry, biology, medicine, security, engineering and in the earth, planetary and environmental sciences, all including dosimetry. Nuclear techniques are defined in the broadest sense and both experimental and theoretical papers are welcome. They include the development and use of α- and β-particles, X-rays and γ-rays, neutrons and other nuclear particles and radiations from all sources, including radionuclides, synchrotron sources, cyclotrons and reactors and from the natural environment.
The journal aims to publish papers with significance to an international audience, containing substantial novelty and scientific impact. The Editors reserve the rights to reject, with or without external review, papers that do not meet these criteria.
Papers dealing with radiation processing, i.e., where radiation is used to bring about a biological, chemical or physical change in a material, should be directed to our sister journal Radiation Physics and Chemistry.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
