Yumiao Liu , Qing Pang , Binbin Chen , Zizhen Zhu , Jiabin Shen , Pengfei Zhang
{"title":"Synthesis of SCD3-containing bicyclo[1.1.1]pentanes enabled by photocatalyzed difunctionalization of [1.1.1]propellane","authors":"Yumiao Liu , Qing Pang , Binbin Chen , Zizhen Zhu , Jiabin Shen , Pengfei Zhang","doi":"10.1016/j.mcat.2024.114592","DOIUrl":null,"url":null,"abstract":"<div><div>Bicyclo[1.1.1]pentanes (BCPs) have emerged as appealing bioisosteres for <em>para</em>-substituted benzene rings in drug design. In this study, we report an intermolecular photocatalytic addition of [1.1.1]propellane and <em>S</em>-(methyl-<em>d</em><sub>3</sub>) arylsulfonothioates to synthesize novel deuterium-containing BCPs derivatives <em>via</em> energy transfer processes (EnT). This efficient and green protocol provides an access to introduce deuterium into BCP scaffolds and enriches the present library of BCPs compounds for drug design.</div></div>","PeriodicalId":393,"journal":{"name":"Molecular Catalysis","volume":"569 ","pages":"Article 114592"},"PeriodicalIF":3.9000,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular Catalysis","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468823124007740","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Bicyclo[1.1.1]pentanes (BCPs) have emerged as appealing bioisosteres for para-substituted benzene rings in drug design. In this study, we report an intermolecular photocatalytic addition of [1.1.1]propellane and S-(methyl-d3) arylsulfonothioates to synthesize novel deuterium-containing BCPs derivatives via energy transfer processes (EnT). This efficient and green protocol provides an access to introduce deuterium into BCP scaffolds and enriches the present library of BCPs compounds for drug design.
期刊介绍：
Molecular Catalysis publishes full papers that are original, rigorous, and scholarly contributions examining the molecular and atomic aspects of catalytic activation and reaction mechanisms. The fields covered are:
Heterogeneous catalysis including immobilized molecular catalysts
Homogeneous catalysis including organocatalysis, organometallic catalysis and biocatalysis
Photo- and electrochemistry
Theoretical aspects of catalysis analyzed by computational methods
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
