Pushpa V. Malekar , Ganesh V. More , Chepuri V. Ramana
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引用次数: 0
Abstract
The enantioselective transfer hydrogenation of racemic β-keto γ-lactams via dynamic kinetic resolution using a chiral Ru(II) catalyst has been developed for the synthesis of optically active β-hydroxyl lactams with excellent conversion (up to 99 %), high diastereomeric ratio (dr 93:07) and enantiomeric selectivity (89 % ee). The reaction proceeded by using HCO2H/Et3N as hydrogen donor and features mild, additive free reaction conditions, fast crystallization, broad substrate scope, and an operationally simpler setup than that for molecular hydrogenation.
期刊介绍：
Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry.
Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters.
Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.
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