Association of Serum Levels of Terpenes With Metabolic Syndrome and Its Components in Adults

IF 4.3 2区环境科学与生态学 Q1 CONSTRUCTION & BUILDING TECHNOLOGY Indoor air Pub Date : 2024-10-08 DOI:10.1155/2024/7714151

Jianmei Zhou, Rongfang Zhou, Xiaoling Lv, Jing Zhang, Wei Qiao, Genxiang Mao, Qing Wu

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Abstract

Aim: Environmental exposure constitutes a significant determinant in the pathogenesis of metabolic syndrome (MetS). Nevertheless, the contribution of environmental factors to MetS remains ambiguous. The present study was aimed at investigating the correlation between serum terpenes and the risk of MetS in the general population.

Methods: A cross-sectional study was conducted among 1266 individuals from the 2013–2014 National Health and Nutrition Examination Survey (NHANES). Serum terpenes and MetS risk were analyzed using a weighted logistic regression model. Weighted quantile sum (WQS) regression was utilized to explore the relationship between the mixture of serum terpenes and MetS. The restricted cubic spline (RCS) method was employed to assess the dose–response relationship between them. All data and analyses were conducted using the “Survey” package in R software (Version 4.3.2).

Results: The study population, with an average age of 46.82 ± 0.46 years and a body mass index (BMI) of 28.97 kg/m², consisted of 48.15% males and 67.99% Whites. Among the participants, 35.78% were diagnosed with MetS. The weighted logistic regression showed that tertiles of serum levels of α-pinene, β-pinene, and limonene were positively correlated with MetS risk with a OR value of 1.90 (1.14, 3.16), 2.02 (1.23, 3.31), and 2.35 (1.33, 4.13) and elevated triglycerides (TGs) with a OR of 2.36 (1.63, 3.43), 3.51 (2.30, 5.38), and 3.96 (2.55, 6.15) (all p_trend < 0.05). The WQS regression indicated a positive association between serum terpene mixture and MetS risk (OR = 1.65, 95% CI: 1.18–2.3), increased TG (OR = 2.69, 95% CI: 1.94–3.71), and reduced high-density lipoprotein cholesterol (HDL-C) (OR = 1.46, 95% CI: 1.03–2.07) (all p_trend < 0.01). The RCS analysis further supported the dose–response relationship.

Conclusion: This study suggested potential adverse effects of terpene exposure on human health, emphasizing the importance of environmental interventions in maintaining health.

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萜类化合物血清水平与成人代谢综合征及其组成部分的关系

目的：环境暴露是代谢综合征（MetS）发病机制的一个重要决定因素。然而，环境因素对代谢综合征的影响仍不明确。本研究旨在调查普通人群血清萜类化合物与 MetS 风险之间的相关性：方法：本研究对 2013-2014 年美国国家健康与营养调查（NHANES）中的 1266 人进行了横断面研究。采用加权逻辑回归模型对血清萜类化合物和 MetS 风险进行了分析。加权量子和（WQS）回归用于探讨血清萜烯混合物与 MetS 之间的关系。受限立方样条线（RCS）法用于评估两者之间的剂量-反应关系。所有数据和分析均使用 R 软件（4.3.2 版）中的 "Survey "软件包进行：研究对象的平均年龄为 46.82 ± 0.46 岁，体重指数（BMI）为 28.97 kg/m2，其中男性占 48.15%，白人占 67.99%。其中，35.78%的参与者被诊断出患有 MetS。加权逻辑回归结果表明，血清中 α-蒎烯、β-蒎烯和柠檬烯水平的 tertiles 与 MetS 风险呈正相关，OR 值分别为 1.90（1.14，3.16）、2.02（1.23，3.31）和 2.35（1.33，4.13）；甘油三酯（TGs）升高的 OR 值为 2.36（1.63，3.43）、3.51（2.30，5.38）和 3.96（2.55，6.15）（均为 0.05）。WQS 回归结果表明，血清萜烯混合物与 MetS 风险（OR = 1.65，95% CI：1.18-2.3）、TG 增加（OR = 2.69，95% CI：1.94-3.71）和高密度脂蛋白胆固醇（HDL-C）降低（OR = 1.46，95% CI：1.03-2.07）呈正相关（均为 0.01）。RCS分析进一步证实了剂量反应关系：这项研究表明，接触萜烯可能会对人体健康产生不利影响，强调了环境干预在维护健康方面的重要性。

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来源期刊

Indoor air 环境科学-工程：环境

CiteScore

10.80

自引率

10.30%

发文量

175

审稿时长

3 months

期刊介绍： The quality of the environment within buildings is a topic of major importance for public health. Indoor Air provides a location for reporting original research results in the broad area defined by the indoor environment of non-industrial buildings. An international journal with multidisciplinary content, Indoor Air publishes papers reflecting the broad categories of interest in this field: health effects; thermal comfort; monitoring and modelling; source characterization; ventilation and other environmental control techniques. The research results present the basic information to allow designers, building owners, and operators to provide a healthy and comfortable environment for building occupants, as well as giving medical practitioners information on how to deal with illnesses related to the indoor environment.