Epstein–Barr Virus-Associated Lymphoproliferative Disorders/Lymphoma with Skin Manifestations as the Primary Symptom: A Systematic Review

IF 3.7 4区 医学 Q1 DERMATOLOGY Dermatologic Therapy Pub Date : 2024-10-10 DOI:10.1155/2024/6751485
Fen Li, Haonan Feng, Yan Zeng
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Abstract

Background. Epstein–Barr virus (EBV) associated skin lesions have been mentioned in case report studies under multiple kinds of lymphoproliferative disorders/lymphoma diagnoses. However, due to the rarity and scattered reporting of cases, it is still unclear whether the related skin symptoms and their pathological findings can guide the clinical diagnosis and treatment of EBV-associated lymphoproliferative disease/lymphoma. Methods. In this review, we summarized the skin symptoms and clinicopathological features mentioned by previously reported cases of EBV-associated lymphoproliferative disorders/lymphoma to assist future clinical diagnosis. The inclusion criteria were based on the population, intervention, comparator, outcomes, and study designs. An electronic search was conducted by September 2023, and the following databases were used: PubMed, EMBASE, Cochrane Library, and Web of Science. Search keywords included “Epstein-Barr Virus Infections,” “Herpesvirus 4, Human,” “Lymphoma,” “Lymphoproliferative Disorders,” and “skin.” Results. The primary outcome was the clinical skin features and pathological findings of EBV-associated lymphoproliferative disease/lymphoma patients. Although it seems unrealistic to differentiate between patients with EBV-related lymphoproliferative disorders/lymphomas with different diagnoses on the basis of cutaneous symptoms and pathological findings alone, based on the evidence summarized in previous case reports, the clinical importance of EBV detection and identification in the differential diagnosis of lymphomas and lymphoproliferative disorders should be recognized. Conclusion. Given the homogeneity of risk factors associated with disease progression found in EBV-associated lymphoproliferative disease/lymphoma patients during the review, future studies can focus on summarizing skin symptoms and pathological outcomes based on possible risk factors for further deterioration in these patients.

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以皮肤表现为主要症状的爱泼斯坦-巴氏病毒相关淋巴组织增生性疾病/淋巴瘤:系统综述
背景。在多种淋巴增生性疾病/淋巴瘤诊断的病例报告研究中,都提到了与爱泼斯坦-巴氏病毒(EBV)相关的皮肤病变。然而,由于病例罕见且报告分散,相关皮肤症状及其病理结果能否指导 EBV 相关淋巴组织增生性疾病/淋巴瘤的临床诊断和治疗仍不明确。方法。在这篇综述中,我们总结了之前报道的EB病毒相关淋巴细胞增生性疾病/淋巴瘤病例中提到的皮肤症状和临床病理特征,以帮助未来的临床诊断。纳入标准基于人群、干预措施、比较对象、结果和研究设计。在 2023 年 9 月之前进行了电子检索,并使用了以下数据库:PubMed、EMBASE、Cochrane Library 和 Web of Science。检索关键词包括 "Epstein-Barr 病毒感染"、"人类疱疹病毒 4"、"淋巴瘤"、"淋巴增生性疾病 "和 "皮肤"。结果。主要结果是 EBV 相关淋巴增生性疾病/淋巴瘤患者的临床皮肤特征和病理结果。虽然仅凭皮肤症状和病理结果来区分不同诊断的 EBV 相关淋巴细胞增生性疾病/淋巴瘤患者似乎并不现实,但根据以往病例报告中总结的证据,应认识到 EBV 检测和识别在淋巴瘤和淋巴细胞增生性疾病鉴别诊断中的临床重要性。结论鉴于在回顾性研究中发现与 EBV 相关的淋巴组织增生性疾病/淋巴瘤患者疾病进展相关的风险因素具有同质性,今后的研究可根据这些患者病情进一步恶化的可能风险因素,重点总结皮肤症状和病理结果。
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来源期刊
Dermatologic Therapy
Dermatologic Therapy 医学-皮肤病学
CiteScore
7.00
自引率
8.30%
发文量
711
审稿时长
3 months
期刊介绍: Dermatologic Therapy has been created to fill an important void in the dermatologic literature: the lack of a readily available source of up-to-date information on the treatment of specific cutaneous diseases and the practical application of specific treatment modalities. Each issue of the journal consists of a series of scholarly review articles written by leaders in dermatology in which they describe, in very specific terms, how they treat particular cutaneous diseases and how they use specific therapeutic agents. The information contained in each issue is so practical and detailed that the reader should be able to directly apply various treatment approaches to daily clinical situations. Because of the specific and practical nature of this publication, Dermatologic Therapy not only serves as a readily available resource for the day-to-day treatment of patients, but also as an evolving therapeutic textbook for the treatment of dermatologic diseases.
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