BCAS1+ oligodendrocytes aid remyelination in MS

IF 28.2 1区医学 Q1 CLINICAL NEUROLOGY Nature Reviews Neurology Pub Date : 2024-10-14 DOI:10.1038/s41582-024-01031-0

Heather Wood

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BCAS1+ 少突胶质细胞有助于多发性硬化症的髓鞘再形成

最近的一份报告确定了大脑皮层中表达脑富集髓鞘相关蛋白1（BCAS1）的少突胶质细胞群，它们似乎有助于多发性硬化症（MS）的再髓鞘化。对多发性硬化症早期患者和脱髓鞘小鼠模型的大脑皮层组织进行分析后发现，BCAS1+少突胶质细胞数量丰富，并在脱髓鞘事件发生时呈现活化的髓鞘化形态。然而，在慢性多发性硬化症患者中，皮质BCAS1+少突胶质细胞的数量减少了，这可能有助于解释为什么再髓鞘化在疾病晚期会失败。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Neurology 医学-临床神经学

CiteScore

29.90

自引率

0.80%

发文量

138

审稿时长

6-12 weeks

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