A nanostructure based voltammetric platform constructed with carbon nanofibers and erbium nanoparticles for the determination of yohimbine and its DNA binding

IF 4.1 3区化学 Q1 CHEMISTRY, ANALYTICAL Journal of Electroanalytical Chemistry Pub Date : 2024-10-10 DOI:10.1016/j.jelechem.2024.118710

Şehriban Düzmen, Tuğçe Teker, Mehmet Aslanoglu

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Abstract

Yohimbine is a natural supplement to improve symptoms of erectile dysfunction. Yohimbine supplementations are also used for body composition and weight loss. Yohimbine may cause several complications including nausea, abdominal pain, dizziness, nervousness, anxiety and severe acute intoxication. Thus, a sensitive method of analysis is of requirement since many yohimbine-containing supplements are reported to be inaccurately labelled. For this purpose, a novel sensor was constructed by modifying a glassy carbon electrode (GCE) with ultrasonication-assisted preparation of erbium oxide nanoparticles and carbon nanofibers (GCE/CNFs@Er₂O₃) for the measurement of yohimbine. An electro-active surface area of 0.054, 0.196 and 0.330 cm² was calculated for GCE, GCE/CNFs and GCE/CNFs@Er₂O₃, respectively. The impact of nanoparticles of Er₂O₃ resulted in a good synergistic effect, leading to a large increase in the peak response and a remarkable change in the oxidation potential (Epa) of yohimbine. The novel platform exhibited a linear range of 2.0 × 10^-8 ∼ 1.6 × 10^-5 M and a detection limit of 8.0 × 10^-9 M. GCE/CNFs@Er₂O₃ exhibited high accuracy and excellent precision for the analysis of yohimbine capsule and urine. In addition, a standard Gibbs free-energy change (ΔG⁰) of –22.7 kJ/mol at 25 ℃ reveals that the interaction of yohimbine with DNA occurs spontaneously.

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利用碳纳米纤维和铒纳米颗粒构建的基于纳米结构的伏安平台，用于测定育亨宾及其 DNA 结合力

育亨宾是一种改善勃起功能障碍症状的天然补充剂。育亨宾补充剂还可用于增强体质和减肥。育亨宾可能会引起多种并发症，包括恶心、腹痛、头晕、紧张、焦虑和严重急性中毒。因此，需要一种灵敏的分析方法，因为据报道，许多含有育亨宾的补充剂的标签并不准确。为此，我们通过超声辅助制备氧化铒纳米颗粒和碳纳米纤维（GCE/CNFs@Er2O3）对玻璃碳电极（GCE）进行改性，构建了一种新型传感器，用于测量育亨宾。计算得出 GCE、GCE/CNFs 和 GCE/CNFs@Er2O3 的电活性表面积分别为 0.054、0.196 和 0.330 cm2。Er2O3 纳米粒子的影响产生了良好的协同效应，使峰值响应大幅增加，并显著改变了育亨宾的氧化电位（Epa）。该新型平台的线性范围为 2.0 × 10-8 ∼ 1.6 × 10-5 M，检测限为 8.0 × 10-9 M。此外，25 ℃ 时的标准吉布斯自由能变化（ΔG0）为 -22.7 kJ/mol，这表明育亨宾与 DNA 的相互作用是自发发生的。

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来源期刊

Journal of Electroanalytical Chemistry 化学-电化学

CiteScore

7.80

自引率

6.70%

发文量

912

审稿时长

2.4 months

期刊介绍： The Journal of Electroanalytical Chemistry is the foremost international journal devoted to the interdisciplinary subject of electrochemistry in all its aspects, theoretical as well as applied. Electrochemistry is a wide ranging area that is in a state of continuous evolution. Rather than compiling a long list of topics covered by the Journal, the editors would like to draw particular attention to the key issues of novelty, topicality and quality. Papers should present new and interesting electrochemical science in a way that is accessible to the reader. The presentation and discussion should be at a level that is consistent with the international status of the Journal. Reports describing the application of well-established techniques to problems that are essentially technical will not be accepted. Similarly, papers that report observations but fail to provide adequate interpretation will be rejected by the Editors. Papers dealing with technical electrochemistry should be submitted to other specialist journals unless the authors can show that their work provides substantially new insights into electrochemical processes.