Shaping hematopoietic cell ecosystems through galectin-glycan interactions

IF 7.4 2区 医学 Q1 IMMUNOLOGY Seminars in Immunology Pub Date : 2024-07-01 DOI:10.1016/j.smim.2024.101889
Mirta Schattner , Bethan Psaila , Gabriel A. Rabinovich
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Abstract

Hematopoiesis- the formation of blood cell components- continually replenishes the blood system during embryonic development and postnatal lifespans. This coordinated process requires the synchronized action of a broad range of cell surface associated proteins and soluble mediators, including growth factors, cytokines and lectins. Collectively, these mediators control cellular communication, signalling, commitment, proliferation, survival and differentiation. Here we discuss the role of galectins – an evolutionarily conserved family of glycan-binding proteins – in the establishment and dynamic remodelling of hematopoietic niches. We focus on the contribution of galectins to B and T lymphocyte development and selection, as well as studies highlighting the role of these proteins in myelopoiesis, with particular emphasis on erythropoiesis and megakaryopoiesis. Finally, we also highlight recent findings suggesting the role of galectin-1, a prototype member of this protein family, as a key pathogenic factor and therapeutic target in myelofibrosis. Through extracellular or intracellular mechanisms, galectins can influence the fate and function of distinct hematopoietic progenitors and fine-tune the final repertoire of blood cells, with critical implications in a wide range of physiologically vital processes including innate and adaptive immunity, immune tolerance programs, tissue repair, regeneration, angiogenesis, inflammation, coagulation and oxygen delivery. Additionally, positive or negative regulation of galectin-driven circuits may contribute to a broad range of blood cell disorders.
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通过加连蛋白-聚糖相互作用塑造造血细胞生态系统
造血--血细胞成分的形成--在胚胎发育和出生后的生命周期中不断补充血液系统。这一协调过程需要多种细胞表面相关蛋白和可溶性介质(包括生长因子、细胞因子和凝集素)的同步作用。这些介质共同控制着细胞通信、信号、承诺、增殖、存活和分化。在这里,我们将讨论半整联蛋白(进化保守的糖结合蛋白家族)在造血龛的建立和动态重塑中的作用。我们重点讨论了半整联蛋白对 B 淋巴细胞和 T 淋巴细胞发育和选择的贡献,以及强调这些蛋白在骨髓造血中作用的研究,尤其侧重于红细胞生成和巨核细胞生成。最后,我们还重点介绍了最近的研究结果,这些结果表明,该蛋白家族的原型成员 galectin-1 是骨髓纤维化的关键致病因素和治疗靶点。通过细胞外或细胞内机制,galectins 可影响不同造血祖细胞的命运和功能,并对血细胞的最终种类进行微调,从而对包括先天性和适应性免疫、免疫耐受程序、组织修复、再生、血管生成、炎症、凝血和氧输送在内的一系列重要生理过程产生重要影响。此外,galectin 驱动回路的正向或负向调节可能导致多种血细胞疾病。
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来源期刊
Seminars in Immunology
Seminars in Immunology 医学-免疫学
CiteScore
11.40
自引率
1.30%
发文量
50
审稿时长
89 days
期刊介绍: Seminars in Immunology is a specialized review journal that serves as a valuable resource for scientists in the field of immunology. The journal's approach is thematic, with each issue dedicated to a specific topic of significant interest to immunologists. It covers a wide range of research areas, from the molecular and cellular foundations of the immune response to the potential for its manipulation, highlighting recent advancements in these areas. Each thematic issue is curated by a guest editor, who is recognized as an expert in the field internationally. The content of each issue typically includes six to eight authoritative invited reviews, which delve into various aspects of the chosen topic. The goal of these reviews is to provide a comprehensive, coherent, and engaging overview of the subject matter, ensuring that the information is presented in a timely manner to maintain its relevance. The journal's commitment to quality and timeliness is further supported by its inclusion in the Scopus database, which is a leading abstract and citation database of peer-reviewed literature. Being indexed in Scopus helps to ensure that the journal's content is accessible to a broad audience of researchers and professionals in immunology and related fields.
期刊最新文献
Complement regulation in tumor immune evasion Galectins and Host–Pathogen Interactions: The roles in viral infections Editorial Board ABO blood groups and galectins: Implications in transfusion medicine and innate immunity Shaping hematopoietic cell ecosystems through galectin-glycan interactions
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