CeO2/conjugated polymer heterostructures for dual-modal phototherapy with antibacterial applications

IF 2.7 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY New Journal of Chemistry Pub Date : 2024-09-24 DOI:10.1039/D4NJ02999B

Wanli Guo, Xiaojie Sun, Yanbin Meng, Peiyi Bai, Zhihui Guo, Xiaorui Tian and Peng Duan

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Abstract

This study investigated the synthesis and application of cerium oxide/conjugated polymer (CeO₂/CP) heterostructures for dual-modal phototherapy with a focus on antibacterial applications. CeO₂ nanoparticles were synthesized via a precipitation method and combined with a conjugated polymer, polythiophene, in a 40/60 wt% ratio to form a composite that leveraged the photothermal properties of CeO₂ and the photodynamic capabilities of the polymer. The composite was analyzed with Transmission Electron Microscopy (TEM), X-ray diffraction (XRD), and UV-visible spectroscopy. Its photothermal efficiency and reactive oxygen species (ROS) generation were assessed under near-infrared (NIR) irradiation. Antibacterial tests against E. coli and MRSA demonstrated significant growth inhibition, particularly under elevated temperatures and repeated NIR irradiation cycles. The findings suggested that the CeO₂/CP composite provided enhanced photothermal and photodynamic therapy, showing potential for effective use in medical applications aimed at infection control and enhanced tissue repair.

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用于抗菌双模式光疗的 CeO2/共轭聚合物异质结构

本研究探讨了氧化铈/共轭聚合物（CeO2/CP）异质结构的合成和应用，以抗菌为重点，用于双模式光疗。通过沉淀法合成了二氧化铈纳米粒子，并以 40/60 wt% 的比例与共轭聚合物聚噻吩结合，形成了一种复合材料，充分利用了二氧化铈的光热特性和聚合物的光动力能力。该复合材料通过透射电子显微镜（TEM）、X 射线衍射（XRD）和紫外可见光谱进行了分析。在近红外（NIR）照射下，对其光热效率和活性氧（ROS）生成进行了评估。针对大肠杆菌和 MRSA 的抗菌测试表明，特别是在高温和反复近红外辐照循环条件下，该物质具有显著的生长抑制作用。研究结果表明，二氧化铈/氯化石蜡复合材料可提供增强的光热和光动力疗法，显示出在旨在控制感染和增强组织修复的医疗应用中有效使用的潜力。

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