Delivery of TGFβ3 from Magnetically Responsive Coaxial Fibers Reduces Spinal Cord Astrocyte Reactivity In Vitro (Adv. Biology 10/2024)

IF 3.2 3区生物学 Q3 MATERIALS SCIENCE, BIOMATERIALS Advanced biology Pub Date : 2024-10-13 DOI:10.1002/adbi.202470101

Jessica L. Funnell, Jasper Fougere, Diana Zahn, Silvio Dutz, Ryan J. Gilbert

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Abstract

Drug Delivery

Spinal cord injury (SCI) is a devastating condition that severely impacts patient quality of life, and there are no available treatments that restore lost function. Biomaterials can provide local, sustained release of therapeutics, but drug-releasing biomaterials do not address variability in injury severity. To tune delivery to a unique injury, Ryan J. Gilbert and co-workers developed a fibrous scaffold that can be stimulated with a magnetic field to alter the release rate of a growth factor. The authors found that sustained release of the growth factor resulted in a greater reduction of spinal cord astrocyte reactivity compared to bolus delivery in vitro. The astrocytes treated with the drug-releasing scaffold supported sensory neuron growth in coculture, shown in the flourescence image. Article number 2300531 provides a foundation for developing biomaterials capable of tunable growth factor release in response to externally applied magnetic fields for SCI treatment.

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磁响应同轴纤维传递 TGFβ3 可降低体外脊髓星形胶质细胞的反应性（生物学进展 10/2024）

给药脊髓损伤（SCI）是一种严重影响患者生活质量的灾难性疾病，目前还没有能够恢复患者丧失功能的治疗方法。生物材料可以提供局部、持续的治疗药物释放，但药物释放生物材料无法解决损伤严重程度不同的问题。Ryan J. Gilbert 及其合作者开发了一种纤维支架，可以通过磁场刺激来改变生长因子的释放率，从而调整对独特损伤的给药。作者发现，与体外注射相比，持续释放生长因子能更有效地降低脊髓星形胶质细胞的反应性。用药物释放支架处理的星形胶质细胞在共培养过程中支持了感觉神经元的生长，如荧光图像所示。文章编号 2300531 为开发能够根据外加磁场调节生长因子释放的生物材料治疗 SCI 奠定了基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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