Puja Agarwal, Lisa L. Barnes, Klodian Dhana, Xiaoran Liu, Yanyu Zhang, Todd Beck, Marilyn C. Cornelis, Christy Tangney, Kumar B. Rajan
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引用次数: 0
Abstract
INTRODUCTION
We examined the Mediterranean–Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diet's association with cognitive decline by race among older adults in the Chicago Health and Aging Project.
METHODS
Five thousand two hundred fifty-nine participants (73.5 [± 6.0] years, 62% Black participants, 62% female) completed a food frequency questionnaire, and two or more cognitive assessments over 7.8 ± 4.6 years.
RESULTS
Overall, higher MIND diet was associated with slower cognitive decline (p for trend = 0.0025). The MIND score (range:0-15) was different between Black and White older adults(6.97 vs. 7.12, p = 0.010). Compared to the lowest tertile, among White participants, the two highest tertiles (MIND score –7: β = 0.0121 [95% confidence interval [CI]: 0.0006, 0.0237]; MIND score –8.5: β = 0.0146 [95% CI: 0.0003, 0.0260]) and among Black participants, only the highest tertile (MIND score –8.5: β = 0.0088 [95% CI: 0.0003, 0.0172]) had association with cognitive decline. Vascular and lifestyle factors attenuated the association only for Black older adults.
DISCUSSION
The MIND diet was associated with slower cognitive decline in Black and White older adults, but this may vary with other lifestyle and vascular factors. Further research is warranted on race-specific cultural diets considering other risk factors for cognitive decline.
Highlights
The intake of Mediterranean–Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diet components varies by race.
The MIND diet may slow cognitive decline in both Black and White older adults.
This association may vary with other lifestyle and vascular risk factors.
我们研究了 "芝加哥健康与老龄化项目"（Chicago Health and Aging Project）中不同种族老年人的地中海饮食法（Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay，MIND）与认知能力下降的关系。
期刊介绍：
Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.
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