Identification of a Novel ECM Remodeling Macrophage Subset in AKI to CKD Transition by Integrative Spatial and Single-Cell Analysis (Adv. Sci. 38/2024)
Yi-Lin Zhang, Tao-Tao Tang, Bin Wang, Yi Wen, Ye Feng, Qing Yin, Wei Jiang, Yue Zhang, Zuo-Lin Li, Min Wu, Qiu-Li Wu, Jing Song, Steven D. Crowley, Hui-Yao Lan, Lin-Li Lv, Bi-Cheng Liu
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Abstract
Spatial Transcriptomic
The cover depicts a Chinese Taoist concept: Yang promotes tissue repair through dynamic equilibrium, while imbalance of Yin disrupts tissue's ability to regenerate, leading to fibrosis. In article number 2309752, Yi-Lin Zhang, Lin-Li Lv, Bi-Cheng Liu, and their co-workers map the spatiotemporal heterogeneity of macrophages in AKI-to-CKD transition using integration spatial single-cell data and identified a novel subset that highly linked to fibrogenesis.
期刊介绍：
Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.
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