Front Cover: Vinyl 3-(Dimethylamino)propanoate as an Irreversible Acyl Donor Reagent in a Chromatography-free Lipase-Catalyzed Kinetic Resolution of sec-Alcohols (ChemBioChem 20/2024)
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引用次数: 0
Abstract
The cover image depicts a novel “acid-washable” acyl donor, namely vinyl 3-(dimethylamino)propanoate, dedicated to a chromatography-free lipase-catalyzed kinetic resolution (KR) of racemic sec-alcohols. The employed vinyl ester allows the synthesis of both enantiomers of a range of structurally diverse benzylic alcohols with high conversions and excellent enantioselectivity, and, most importantly, significantly simplifies enzymatic KR by eliminating a silica gel chromatographic separation, leading to a more sustainable and ecologically friendly bioprocess. More details can be found in article 10.1002/cbic.202400394 by Beata Zdun and Paweł Borowiecki. Cover image designed by Paweł Borowiecki and created by Paulina Marek-Urban.
期刊介绍：
ChemBioChem (Impact Factor 2018: 2.641) publishes important breakthroughs across all areas at the interface of chemistry and biology, including the fields of chemical biology, bioorganic chemistry, bioinorganic chemistry, synthetic biology, biocatalysis, bionanotechnology, and biomaterials. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies, and supported by the Asian Chemical Editorial Society (ACES).
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