Reactive Oxygen Species-Responsive Pillararene-Embedded Covalent Organic Frameworks with Amplified Antimicrobial Photodynamic Therapy for the Targeted Elimination of Periodontitis Pathogens

IF 9.6 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY Nano Letters Pub Date : 2024-10-17 DOI:10.1021/acs.nanolett.4c03788

Shuang Liang, Meng-Hao Li, Man-Lin Qi, Hui Hui, Hong-Pu Zhang, Jing Zhou, Lin Wang, Ying-Wei Yang

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Abstract

Reactive oxygen species (ROS)-responsive drug delivery systems possess immense potential for targeted delivery and controlled release of therapeutics. However, the rapid responsiveness to ROS and sustained release of antibacterial drugs are often limited by the challenging microenvironment of periodontitis. Integrating ROS-responsive drug delivery systems with photocatalytic technologies presents a strategic approach to overcome these limitations. Herein, a pillararene-embedded covalent organic framework (PCOF) incorporating the antibacterial prodrug thioacetal (TA) has been developed to treat periodontitis. This drug-loaded nanoplatform, namely TA-loaded PCOF, utilizes the self-amplifying ROS property to enhance therapeutic efficacy. PCOFs demonstrate exceptional photosensitivity and ROS generation capabilities when employed as drug carriers. When exposed to ROS, TA within the nanoplatform was activated and cleaved into cinnamaldehyde (CA), a highly potent antibacterial compound. By leveraging visible light to activate the site-specific infection targeting, TA-loaded PCOF effectively alleviated periodontitis, thereby advancing the field of antibacterial drug delivery systems.

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具有活性氧反应的柱状烯嵌入共价有机框架，可放大抗菌光动力疗法，用于靶向消除牙周炎病原体

活性氧（ROS）反应给药系统在靶向给药和控制释放治疗药物方面具有巨大的潜力。然而，抗菌药物对 ROS 的快速响应和持续释放往往受到牙周炎微环境挑战的限制。将 ROS 响应型给药系统与光催化技术相结合，是克服这些限制的战略方法。在此，我们开发了一种包含抗菌原药硫代乙醛（TA）的柱状烯嵌入式共价有机框架（PCOF），用于治疗牙周炎。这种载药纳米平台（即 TA 载药 PCOF）利用自放大 ROS 特性来提高疗效。当 PCOF 用作药物载体时，它具有优异的光敏性和产生 ROS 的能力。当暴露于 ROS 时，纳米平台内的 TA 被激活并裂解成肉桂醛（CA），这是一种高效抗菌化合物。通过利用可见光激活特异性感染靶点，TA负载的PCOF有效缓解了牙周炎，从而推动了抗菌药物递送系统领域的发展。

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来源期刊

Nano Letters 工程技术-材料科学：综合

CiteScore

16.80

自引率

2.80%

发文量

1182

审稿时长

1.4 months

期刊介绍： Nano Letters serves as a dynamic platform for promptly disseminating original results in fundamental, applied, and emerging research across all facets of nanoscience and nanotechnology. A pivotal criterion for inclusion within Nano Letters is the convergence of at least two different areas or disciplines, ensuring a rich interdisciplinary scope. The journal is dedicated to fostering exploration in diverse areas, including: - Experimental and theoretical findings on physical, chemical, and biological phenomena at the nanoscale - Synthesis, characterization, and processing of organic, inorganic, polymer, and hybrid nanomaterials through physical, chemical, and biological methodologies - Modeling and simulation of synthetic, assembly, and interaction processes - Realization of integrated nanostructures and nano-engineered devices exhibiting advanced performance - Applications of nanoscale materials in living and environmental systems Nano Letters is committed to advancing and showcasing groundbreaking research that intersects various domains, fostering innovation and collaboration in the ever-evolving field of nanoscience and nanotechnology.