{"title":"In-situ chemobiocatalytic conversion of glucose into 2,5-bis(hydroxymethyl)furan by AlCl3/Enterobacter cloacae in biocompatible DMSO-water solvent","authors":"","doi":"10.1016/j.scp.2024.101813","DOIUrl":null,"url":null,"abstract":"<div><div>In-situ chemobiocatalytic production of 2,5-bis(hydroxymethyl)furan (BHMF) from glucose is extremely desirable but challenging owing to the incompatibility issues between two worlds of catalysts. In this study, a robust strain <em>Enterobacter cloacae</em> HA188, which is tolerant to 20% (v/v) DMSO, was used in the direct conversion of glucose into BHMF. The dehydration of glucose into 5-hydroxymethylfurfural (HMF) was catalyzed by AlCl<sub>3</sub> in DMSO at 130 °C for 0.5 h, then water and <em>E. cloacae</em> cells were added and the bio-reduction of HMF was directly performed in 20% (v/v) DMSO at 30 °C for 6 h. Under the optimized conditions, 1000 mM glucose was transformed into HMF at 51.1% yield, which was further converted into BHMF with an overall yield of 47.2%. The BHMF yield was further improved when fructose or sucrose were utilized. This work provided a sustainable way for the production of value-added BHMF from inexpensive glucose under benign conditions.</div></div>","PeriodicalId":22138,"journal":{"name":"Sustainable Chemistry and Pharmacy","volume":null,"pages":null},"PeriodicalIF":5.5000,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sustainable Chemistry and Pharmacy","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2352554124003887","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
In-situ chemobiocatalytic production of 2,5-bis(hydroxymethyl)furan (BHMF) from glucose is extremely desirable but challenging owing to the incompatibility issues between two worlds of catalysts. In this study, a robust strain Enterobacter cloacae HA188, which is tolerant to 20% (v/v) DMSO, was used in the direct conversion of glucose into BHMF. The dehydration of glucose into 5-hydroxymethylfurfural (HMF) was catalyzed by AlCl3 in DMSO at 130 °C for 0.5 h, then water and E. cloacae cells were added and the bio-reduction of HMF was directly performed in 20% (v/v) DMSO at 30 °C for 6 h. Under the optimized conditions, 1000 mM glucose was transformed into HMF at 51.1% yield, which was further converted into BHMF with an overall yield of 47.2%. The BHMF yield was further improved when fructose or sucrose were utilized. This work provided a sustainable way for the production of value-added BHMF from inexpensive glucose under benign conditions.
期刊介绍:
Sustainable Chemistry and Pharmacy publishes research that is related to chemistry, pharmacy and sustainability science in a forward oriented manner. It provides a unique forum for the publication of innovative research on the intersection and overlap of chemistry and pharmacy on the one hand and sustainability on the other hand. This includes contributions related to increasing sustainability of chemistry and pharmaceutical science and industries itself as well as their products in relation to the contribution of these to sustainability itself. As an interdisciplinary and transdisciplinary journal it addresses all sustainability related issues along the life cycle of chemical and pharmaceutical products form resource related topics until the end of life of products. This includes not only natural science based approaches and issues but also from humanities, social science and economics as far as they are dealing with sustainability related to chemistry and pharmacy. Sustainable Chemistry and Pharmacy aims at bridging between disciplines as well as developing and developed countries.