Ultrasound-assisted natural deep eutectic solvents (NaDES) extraction of gentiopicroside, isovitexin, and isogentisin from Gentiana asclepiadea L. biowaste
{"title":"Ultrasound-assisted natural deep eutectic solvents (NaDES) extraction of gentiopicroside, isovitexin, and isogentisin from Gentiana asclepiadea L. biowaste","authors":"","doi":"10.1016/j.scp.2024.101808","DOIUrl":null,"url":null,"abstract":"<div><div>Through the application of green and sustainable practices, this study introduces an innovative approach for the valorization of <em>Gentiana asclepiadea</em> L. herbal dust based on natural deep eutectic solvents (NaDES) coupled with ultrasound-assisted extraction (UAE). NaDES composed of choline chloride and 1,2-propanediol (ChCl:PG) was selected as the most effective for the simultaneous extraction of gentiopicroside, isovitexin, and isogentisin, monitored as markers of three major classes of secondary metabolites in <em>Gentiana</em> L. species. Response surface methodology based on the Box-Behnken design was employed for extraction modeling and optimization. Extraction yields under optimized NaDES-UAE conditions (80 °C, 39.97 min, and 28.30% w/w water in NaDES) were 50.28 mg/g DW for gentiopicroside, 4.17 mg/g DW for isovitexin, and 0.51 mg/g DW for isogentisin. Molecular dynamics results revealed that the extensive hydrogen-bonding network and electrostatic interactions were the most significant contributors to the extraction capacity of the ChCl:PG NaDES mixture. Overall, the high-efficiency and eco-friendly method developed in this study offers a powerful way to use <em>G</em>. <em>asclepiadea</em> biowaste as a promising source of valuable compounds for pharmaceutical formulations.</div></div>","PeriodicalId":22138,"journal":{"name":"Sustainable Chemistry and Pharmacy","volume":null,"pages":null},"PeriodicalIF":5.5000,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sustainable Chemistry and Pharmacy","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2352554124003838","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Through the application of green and sustainable practices, this study introduces an innovative approach for the valorization of Gentiana asclepiadea L. herbal dust based on natural deep eutectic solvents (NaDES) coupled with ultrasound-assisted extraction (UAE). NaDES composed of choline chloride and 1,2-propanediol (ChCl:PG) was selected as the most effective for the simultaneous extraction of gentiopicroside, isovitexin, and isogentisin, monitored as markers of three major classes of secondary metabolites in Gentiana L. species. Response surface methodology based on the Box-Behnken design was employed for extraction modeling and optimization. Extraction yields under optimized NaDES-UAE conditions (80 °C, 39.97 min, and 28.30% w/w water in NaDES) were 50.28 mg/g DW for gentiopicroside, 4.17 mg/g DW for isovitexin, and 0.51 mg/g DW for isogentisin. Molecular dynamics results revealed that the extensive hydrogen-bonding network and electrostatic interactions were the most significant contributors to the extraction capacity of the ChCl:PG NaDES mixture. Overall, the high-efficiency and eco-friendly method developed in this study offers a powerful way to use G. asclepiadea biowaste as a promising source of valuable compounds for pharmaceutical formulations.
期刊介绍:
Sustainable Chemistry and Pharmacy publishes research that is related to chemistry, pharmacy and sustainability science in a forward oriented manner. It provides a unique forum for the publication of innovative research on the intersection and overlap of chemistry and pharmacy on the one hand and sustainability on the other hand. This includes contributions related to increasing sustainability of chemistry and pharmaceutical science and industries itself as well as their products in relation to the contribution of these to sustainability itself. As an interdisciplinary and transdisciplinary journal it addresses all sustainability related issues along the life cycle of chemical and pharmaceutical products form resource related topics until the end of life of products. This includes not only natural science based approaches and issues but also from humanities, social science and economics as far as they are dealing with sustainability related to chemistry and pharmacy. Sustainable Chemistry and Pharmacy aims at bridging between disciplines as well as developing and developed countries.