Polyphenols with anti-inflammatory activity isolated from the whole herbs of Delphinium forrestii var. Viride

IF 2.5 3区医学 Q3 CHEMISTRY, MEDICINAL Fitoterapia Pub Date : 2024-10-15 DOI:10.1016/j.fitote.2024.106259

Yang Xu , Zhiqi Zhang , Bin Liu , Dejuan Sun , Hua Li , Lixia Chen

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Abstract

Delphinium belongs to Ranunculaceae, which is widely distributed in Northwest China. In folk, this genus of plants has analgesic, anti-inflammatory, and insecticidal effects. By studying non-alkaloid components in the whole herbs of Delphinium forrestii, we obtained a total of 11 compounds (1−11), including five new (1–5) and six known polyphenols (6–11). On the basis of chemical evidences and spectral data analysis (UV, Optical rotation data, 1D/2D-NMR and HR-ESI-MS), the structures of new compounds were elucidated. The inhibitory effect of compounds 1–11 on lipopolysaccharide (LPS) induced NO production in RAW 264.7 cells was detected. Compounds 4 and 11 showed significant inhibitory effects. This study indicated the presence of compounds with good anti-inflammatory activity among non-alkaloid components in the whole herbs of Delphinium forrestii.

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从蕨类植物 Delphinium forrestii var. Viride 的全草中分离出的具有抗炎活性的多酚

飞燕草属于毛茛科，广泛分布于中国西北地区。在民间，该属植物具有镇痛、消炎、杀虫等作用。通过对地肤子全草中非生物碱类成分的研究，我们共获得了 11 种化合物（1-11），其中包括 5 种新化合物（1-5）和 6 种已知的多酚类化合物（6-11）。根据化学证据和光谱数据分析（紫外光谱、旋光光谱、1D/2D-NMR 和 HR-ESI-MS），阐明了新化合物的结构。检测了化合物 1-11 对 RAW 264.7 细胞中脂多糖（LPS）诱导的 NO 生成的抑制作用。化合物 4 和 11 具有明显的抑制作用。这项研究表明，在苍术全草的非生物碱成分中，存在具有良好抗炎活性的化合物。

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.