{"title":"Two isoledene-type sesquiterpenoids from a soft coral Heteroxenia sp.","authors":"Viqqi Kurnianda , Hao-Chun Hu , Ping-Jyun Sung , Yasuhiro Hayashi , Kanami Mori-Yasumoto , Ayumi Suetake , Hikari Nakayama , Mina Yasumoto-Hirose , Yuna Tsutsumi , Genta Koja , Yu-Chi Tsai , Takahiro Jomori , Junichi Tanaka","doi":"10.1016/j.tetlet.2024.155323","DOIUrl":null,"url":null,"abstract":"<div><div>Two new isoledene-type sesquiterpenoids, <strong>1</strong> and <strong>2</strong>, were isolated from an Okinawan soft coral <em>Heteroxenia</em> sp. The planar structures and stereochemistry of <strong>1</strong> and <strong>2</strong> were determined by spectroscopic analysis, X-ray crystallography, and comparison of experimental and calculated ECD studies. Antiviral and anti-leishmania assays were performed. Compound <strong>2</strong> exhibited activity against promastigotes of <em>Leishmania major</em>.</div></div>","PeriodicalId":438,"journal":{"name":"Tetrahedron Letters","volume":"151 ","pages":"Article 155323"},"PeriodicalIF":1.5000,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tetrahedron Letters","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0040403924004180","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/10/15 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
Two new isoledene-type sesquiterpenoids, 1 and 2, were isolated from an Okinawan soft coral Heteroxenia sp. The planar structures and stereochemistry of 1 and 2 were determined by spectroscopic analysis, X-ray crystallography, and comparison of experimental and calculated ECD studies. Antiviral and anti-leishmania assays were performed. Compound 2 exhibited activity against promastigotes of Leishmania major.
期刊介绍：
Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.
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