{"title":"Hypoxia-Responsive Hydrogen-Bonded Organic Framework-Mediated Protein Delivery for Cancer Therapy (Adv. Healthcare Mater. 26/2024)","authors":"Xu He, Jian Wang, Xiao Liu, Qingyu Niu, Zhiqiang Li, Banglin Chen, Qingqing Xiong","doi":"10.1002/adhm.202470165","DOIUrl":null,"url":null,"abstract":"<p><b>Hypoxia-Responsive HOF</b></p><p>In article 2400747, Zhiqiang Li, Banglin Chen, Qingqing Xiong, and co-workers report the construction of a polyethylene glycol-modified and hypoxia-responsive nanoscale hydrogen-bonded organic framework (HOF) capable of in situ encapsulation and intracellular delivery of protein for cancer therapy. In hypoxic tumor sites, the azobenzene group is cleaved by reductases, leading to the dissociation of nano-HOF and eventual protein release to exert therapeutic effects.\n\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":null,"pages":null},"PeriodicalIF":10.0000,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adhm.202470165","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Healthcare Materials","FirstCategoryId":"5","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/adhm.202470165","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
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Abstract
Hypoxia-Responsive HOF
In article 2400747, Zhiqiang Li, Banglin Chen, Qingqing Xiong, and co-workers report the construction of a polyethylene glycol-modified and hypoxia-responsive nanoscale hydrogen-bonded organic framework (HOF) capable of in situ encapsulation and intracellular delivery of protein for cancer therapy. In hypoxic tumor sites, the azobenzene group is cleaved by reductases, leading to the dissociation of nano-HOF and eventual protein release to exert therapeutic effects.
期刊介绍：
Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.
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