Expediting the bioactivity of zinc sulfide nanoparticles with copper oxide as a nanocomposite

IF 4.3 2区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY BMC Chemistry Pub Date : 2024-10-19 DOI:10.1186/s13065-024-01320-1
S. Sharmila, A. Saranya, M. Arulprakasajothi, R. Saranya, B. Srimanickam, Sunil Kumar Abel, Faiyaz Shakeel, Md Faiyazuddin
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Abstract

The regulatory role of zinc in bone formation extends to the activation of proteins associated with bone homeostasis. Furthermore, copper is well known for its antibacterial properties. This dual function underscores the significance of zinc and copper in maintaining a balance of bone structure and function. In light of the aforementioned, zinc sulphide/copper oxide nanocomposites were created in this instance using a straightforward coprecipitation technique. Copper oxide was used as a nanocomposite to improve the structural, morphological, and biological performance of zinc sulphide nanoparticles. The X-ray diffraction pattern confirmed a transformation in the crystal structure from cubic to rhombohedral, along with increase in intensity. Fourier transforms infrared analysis indicated the presence of functional groups. Scanning electron microscopy images demonstrated a morphological shift from non-uniform to distinct spherical nanoparticles, impacting the enhancement of material properties. The pathogenic activity of the zinc sulphide/copper oxide nanocomposites was tested against nine bacterial strains. In antimicrobial testing, zinc sulphide/copper oxide nanocomposites showed promising results, particularly against Klebsiella pneumoniae (zone of inhibition: 14 mm at 100 µg/mL compared to 7 mm by standard) and Escherichia coli (zone of inhibition: 11 mm at 100 µg/mL compared to 10 mm by standard) after 24 h with zone of inhibition matching or exceeding that of the standard (chloramphenicol). Zinc sulphide nanoparticles and zinc sulphide/copper oxide nanocomposites were evaluated for their antifungal activity against fungal stains from Trichophyton rubrum, Aspergillus niger, and Aspergillus flavus. After a 24-h period, it was discovered that zinc sulphide/copper oxide nanocomposites were effective against Aspergillus flavus (zone of inhibition: 19.4 mm at 100 µg/mL compared to 6.3 mm by standard) at all concentrations (25–100 mg/mL), with zones of inhibition identical to or greater than those of the standard (fluconazole). Certainly, based on these results, zinc sulphide/copper oxide nanocomposites could be promising materials for drug delivery.

Clinical trial registration: Not applicable.

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用氧化铜作为纳米复合材料提高硫化锌纳米粒子的生物活性
锌在骨骼形成中的调节作用延伸到激活与骨骼稳态相关的蛋白质。此外,铜的抗菌特性也是众所周知的。这种双重功能强调了锌和铜在维持骨骼结构和功能平衡方面的重要性。有鉴于此,本实验采用直接共沉淀技术制造出硫化锌/氧化铜纳米复合材料。氧化铜被用作纳米复合材料,以改善硫化锌纳米粒子的结构、形态和生物学性能。X 射线衍射图样证实,晶体结构从立方体转变为斜方体,同时强度增加。傅立叶变换红外分析表明了官能团的存在。扫描电子显微镜图像显示,纳米颗粒的形态从不规则转变为明显的球形,从而影响了材料性能的提高。硫化锌/氧化铜纳米复合材料的致病活性针对九种细菌菌株进行了测试。在抗菌测试中,硫化锌/氧化铜纳米复合材料显示出良好的效果,尤其是在 24 小时后对肺炎克雷伯菌(抑制区:100 µg/mL 时为 14 毫米,标准为 7 毫米)和大肠埃希菌(抑制区:100 µg/mL 时为 11 毫米,标准为 10 毫米)的抑制区达到或超过了标准(氯霉素)。评估了硫化锌纳米颗粒和硫化锌/氧化铜纳米复合材料对红色毛癣菌、黑曲霉和黄曲霉真菌染色的抗真菌活性。24 小时后发现,硫化锌/氧化铜纳米复合材料在所有浓度(25-100 毫克/毫升)下对黄曲霉都有效(抑制区:100 微克/毫升时为 19.4 毫米,而标准品为 6.3 毫米),抑制区与标准品(氟康唑)相同或更大。当然,基于这些结果,硫化锌/氧化铜纳米复合材料可能是很有前景的给药材料:临床试验注册:不适用。
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来源期刊
BMC Chemistry
BMC Chemistry Chemistry-General Chemistry
CiteScore
5.30
自引率
2.20%
发文量
92
审稿时长
27 weeks
期刊介绍: BMC Chemistry, formerly known as Chemistry Central Journal, is now part of the BMC series journals family. Chemistry Central Journal has served the chemistry community as a trusted open access resource for more than 10 years – and we are delighted to announce the next step on its journey. In January 2019 the journal has been renamed BMC Chemistry and now strengthens the BMC series footprint in the physical sciences by publishing quality articles and by pushing the boundaries of open chemistry.
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