Max E. Huber, Silas L. Wurnig, Dr. Aurélien F. A. Moumbock, Lara Toy, Prof. Dr. Evi Kostenis, Ana Alonso Bartolomé, Dr. Martyna Szpakowska, Dr. Andy Chevigné, Prof. Dr. Stefan Günther, Prof. Dr. Finn K. Hansen, Prof. Dr. Matthias Schiedel
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Abstract
The newly developed NanoBRET assay platform allows the detection of intracellular ligand binding to the chemokine receptors CCR6 and CXCR1, enables equilibrium as well as kinetic binding studies in a cell-free and cellular environment, provides further evidence for the existence of a druggable IABS at CCR6 and CXCR1, and allows mapping of CCR6 and CXCR1 ligands to distinct binding sites of these receptors. More details can be found in article 10.1002/cmdc.202400284 by Finn K. Hansen, Matthias Schiedel, and co-workers.
期刊介绍：
Quality research. Outstanding publications. With an impact factor of 3.124 (2019), ChemMedChem is a top journal for research at the interface of chemistry, biology and medicine. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies.
ChemMedChem publishes primary as well as critical secondary and tertiary information from authors across and for the world. Its mission is to integrate the wide and flourishing field of medicinal and pharmaceutical sciences, ranging from drug design and discovery to drug development and delivery, from molecular modeling to combinatorial chemistry, from target validation to lead generation and ADMET studies. ChemMedChem typically covers topics on small molecules, therapeutic macromolecules, peptides, peptidomimetics, and aptamers, protein-drug conjugates, nucleic acid therapies, and beginning 2017, nanomedicine, particularly 1) targeted nanodelivery, 2) theranostic nanoparticles, and 3) nanodrugs.
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ChemMedChem publishes an attractive mixture of:
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Book and Multimedia Reviews.
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