{"title":"Palladium-catalyzed hydrocarbonylative cross-coupling with two different alkenes","authors":"Hanmin Huang, Yi Chen, Jianing Wu, Yongzheng Ding","doi":"10.1039/d4qo01312c","DOIUrl":null,"url":null,"abstract":"Transition-metal-catalyzed hydrocarbonylation of alkenes has been widely studied, however, the hydrocarbonylation reaction that took place between two alkenes has been largely unexplored. Herein, we report a palladium-catalyzed hydrocarbonylative cross-coupling with two different alkenes to produce structurally diverse β-ketoaldehyde surrogates, which can be easily converted to different types of heterocycles including pyrazole, isoxazole and pyrimidine.","PeriodicalId":97,"journal":{"name":"Organic Chemistry Frontiers","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic Chemistry Frontiers","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1039/d4qo01312c","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
Transition-metal-catalyzed hydrocarbonylation of alkenes has been widely studied, however, the hydrocarbonylation reaction that took place between two alkenes has been largely unexplored. Herein, we report a palladium-catalyzed hydrocarbonylative cross-coupling with two different alkenes to produce structurally diverse β-ketoaldehyde surrogates, which can be easily converted to different types of heterocycles including pyrazole, isoxazole and pyrimidine.
期刊介绍:
Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.