{"title":"Dynamic Nanostructure-Based DNA Logic Gates for Cancer Diagnosis and Therapy.","authors":"Shiyi Bi, Ruowen Yang, Huangxian Ju, Ying Liu","doi":"10.1002/cbic.202400754","DOIUrl":null,"url":null,"abstract":"<p><p>DNA logic gates with dynamic nanostructures have made a profound impact on cancer diagnosis and treatment. Through programming the dynamic structure changes of DNA nanodevices, precise molecular recognition with signal amplification and smart therapeutic strategies have been reported. This enhances the specificity and sensitivity of cancer theranostics, and improves diagnosis precision and treatment outcomes. This review explores the basic components of dynamic DNA nanostructures and corresponding DNA logic gates, as well as their applications for cancer diagnosis and therapies. The dynamic DNA nanostructures would contribute to cancer early detection and personalized treatment.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Bio Materials","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/cbic.202400754","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
引用次数: 0
Abstract
DNA logic gates with dynamic nanostructures have made a profound impact on cancer diagnosis and treatment. Through programming the dynamic structure changes of DNA nanodevices, precise molecular recognition with signal amplification and smart therapeutic strategies have been reported. This enhances the specificity and sensitivity of cancer theranostics, and improves diagnosis precision and treatment outcomes. This review explores the basic components of dynamic DNA nanostructures and corresponding DNA logic gates, as well as their applications for cancer diagnosis and therapies. The dynamic DNA nanostructures would contribute to cancer early detection and personalized treatment.
具有动态纳米结构的 DNA 逻辑门对癌症诊断和治疗产生了深远影响。通过对 DNA 纳米器件的动态结构变化进行编程，精确的分子识别与信号放大和智能治疗策略已被报道。这增强了癌症治疗技术的特异性和灵敏度，提高了诊断精度和治疗效果。本综述探讨了动态 DNA 纳米结构和相应 DNA 逻辑门的基本组成，以及它们在癌症诊断和治疗中的应用。动态 DNA 纳米结构将有助于癌症早期检测和个性化治疗。
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