Complete Blood Collection-based Systemic Inflammation Biomarkers as a Severity Biomarker in Alopecia Areata: A Cross-sectional Study.

IF 3.5 4区 医学 Q1 DERMATOLOGY Acta dermato-venereologica Pub Date : 2024-10-10 DOI:10.2340/actadv.v104.40971
Sihan Deng, Jundong Huang, Min Li, Jia Jian, Wei Shi
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Abstract

Previous studies have suggested that alopecia areata (AA) is an organ-specific disease characterized by loss of immune privilege of hair follicles. However, an increasing body of research indicates that it not only affects the skin but may also be accompanied by systemic inflammatory reactions. Therefore, searching for simple and easily available biomarkers to describe the underlying systemic inflammation in AA patients is of great clinical significance. Complete blood collection-based systemic inflammation biomarkers have been shown to be associated with the severity and prognosis of various skin and autoimmune diseases. They involve multiple cell lineages and can reveal different pathways of immune-inflammatory responses. The aim of this study was to investigate the level of complete blood collection-based systemic inflammation biomarkers in patients with AA, and to analyse their relationship with the disease severity. A total of 302 AA patients and 296 healthy controls were included in this study and the neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), systemic immune inflammation index (SII), and white blood cell/lymphocyte ratio (WLR) were calculated. The differences in these indicators between the 2 groups were compared, and the relationship between NLR, PLR, SII, WLR, and the risk of severe AA were analysed. AA patients had higher NLR, SII, and WLR compared with healthy controls (p = 0.004, 0.002, and 0.002 respectively). PLR and SII were higher in the severe AA group compared with the mild-to-moderate AA patients (p = 0.005 and 0.011 respectively). The risk of severe AA increased with the increasing of PLR, SII, NLR, and WLR (p for trend was 0.001, 0.006, 0.022, and 0.021, respectively). The levels of systemic inflammation biomark-ers in AA patients are higher than in healthy people. NLR, PLR, SII, and WLR are risk factors for severe AA, suggesting a close association between systemic inflammation and disease occurrence in AA patients.

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以全血采集为基础的全身炎症生物标志物作为脱发严重程度的生物标志物:一项横断面研究
以往的研究表明,斑秃(AA)是一种器官特异性疾病,其特点是毛囊失去免疫特权。然而,越来越多的研究表明,这种疾病不仅影响皮肤,还可能伴有全身性炎症反应。因此,寻找简单易得的生物标志物来描述 AA 患者潜在的全身炎症具有重要的临床意义。基于全血采集的全身炎症生物标志物已被证明与各种皮肤病和自身免疫性疾病的严重程度和预后有关。它们涉及多个细胞系,可以揭示免疫炎症反应的不同途径。本研究旨在调查 AA 患者基于全血采集的全身炎症生物标志物的水平,并分析它们与疾病严重程度的关系。本研究共纳入了 302 名 AA 患者和 296 名健康对照者,并计算了中性粒细胞/淋巴细胞比值(NLR)、血小板/淋巴细胞比值(PLR)、全身免疫炎症指数(SII)和白细胞/淋巴细胞比值(WLR)。比较了两组患者在这些指标上的差异,并分析了 NLR、PLR、SII、WLR 与严重 AA 风险之间的关系。与健康对照组相比,AA 患者的 NLR、SII 和 WLR 较高(分别为 p = 0.004、0.002 和 0.002)。与轻度至中度 AA 患者相比,重度 AA 组的 PLR 和 SII 较高(p = 0.005 和 0.011)。严重 AA 的风险随着 PLR、SII、NLR 和 WLR 的增加而增加(趋势 p 分别为 0.001、0.006、0.022 和 0.021)。AA 患者的全身炎症生物标记物水平高于健康人。NLR、PLR、SII 和 WLR 是重度 AA 的风险因素,这表明 AA 患者的全身炎症与疾病的发生密切相关。
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来源期刊
Acta dermato-venereologica
Acta dermato-venereologica 医学-皮肤病学
CiteScore
4.90
自引率
2.80%
发文量
210
审稿时长
6-12 weeks
期刊介绍: Acta Dermato-Venereologica publishes high-quality manuscripts in English in the field of Dermatology and Venereology, dealing with new observations on basic dermatological and venereological research, as well as clinical investigations. Each volume also features a number of Review articles in special areas, as well as short Letters to the Editor to stimulate debate and to disseminate important clinical observations. Acta Dermato-Venereologica has rapid publication times and is amply illustrated with a large number of colour photographs.
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