An Update on Theoretical and Metrological Aspects of the Surface Hydrophobicity of Virus and Virus-Like Particles.

IF 3.2 3区 生物学 Q3 MATERIALS SCIENCE, BIOMATERIALS Advanced biology Pub Date : 2024-10-22 DOI:10.1002/adbi.202400221
Guillaume Sautrey
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Abstract

Viruses are biological entities embodied in protein-based nanoparticles devoid of metabolic activity. Hence, the colloidal, interfacial, and chemical reactivity of virus particles (VPs) profoundly affects the fate of natural and artificial viruses in biotic or abiotic aqueous systems. These rely on the physical chemistry at the outer surface of VPs. In other words, whether wild or synthetic VPs and regardless of the scientific fields involved, taming viruses implies thus managing the physical chemistry at the VP external surface. The surface hydrophobicity (SH) of VPs is a critical feature that must be looked at. Still, the literature dealing with nanoscale hydrophobic domains at the proteinaceous surface of VPs underlying their global SH is like a fragmented puzzle. This article provides an overview of the topic from the perspective of modern protein biophysics for updating the classic physicochemical picture of outer VP/water interfaces hitherto accepted. Patterns of non-polar and "false-polar" patches, expressing variable hydrophobic degrees according to neighboring polar patches, are now drawn. The extensive discussion of reviewed data generates such fresh ideas to explore in the coming years for better modeling the SH of wild virions or engineered virus-based nanoparticles, paving the way for new directions in fundamental virology and virus-based chemistry.

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病毒和类病毒颗粒表面疏水性的理论和计量方面的最新情况。
病毒是以蛋白质为基础的纳米粒子所体现的生物实体,没有新陈代谢活动。因此,病毒颗粒(VPs)的胶体、界面和化学反应性对天然和人造病毒在生物或非生物水系统中的命运有着深远的影响。这些都依赖于病毒颗粒外表面的物理化学作用。换句话说,不管是野生还是人工合成的 VP,也不管涉及哪个科学领域,驯服病毒都意味着对 VP 外表面的物理化学进行管理。VPs 的表面疏水性(SH)是必须关注的一个关键特征。然而,有关 VP 蛋白质表面的纳米级疏水域及其整体疏水性的文献就像一个支离破碎的谜题。本文从现代蛋白质生物物理学的角度概述了这一主题,以更新迄今为止公认的外层 VP/水界面的经典物理化学图景。文章描绘了非极性和 "假极性 "斑块的模式,根据相邻极性斑块表达了不同的疏水程度。通过对综述数据的广泛讨论,我们提出了一些新的想法,以便在未来几年更好地模拟野生病毒或工程化病毒纳米粒子的SH,为基础病毒学和病毒化学的新方向铺平道路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Advanced biology
Advanced biology Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)
CiteScore
6.60
自引率
0.00%
发文量
130
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