HIV Stigma is Associated with Two-Year Decline in Cognitive Performance Among People with HIV.

IF 2.7 2区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH AIDS and Behavior Pub Date : 2024-10-14 DOI:10.1007/s10461-024-04508-7

Mark K Britton, Micaela Lembo, Yancheng Li, Eric C Porges, Robert L Cook, Ronald A Cohen, Charurut Somboonwit, Gladys E Ibañez

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Abstract

HIV stigma is associated with suboptimal clinical outcomes and has been cross-sectionally linked to cognitive deficits in people with HIV (PWH). However, it is unclear whether HIV stigma precedes cognitive decline or vice versa. We examined associations in 303 adult PWH (mean age 50.01 (11.91) years; 46% female; 67% non-Hispanic Black) between the abbreviated Berger Stigma Scale score and longitudinal change across the NIH Toolbox Cognition Battery measures. 89% of participants reported experiencing HIV stigma. In unadjusted analyses, greater HIV stigma was associated with worse attention performance at yearly follow-up visits (B = -0.07, 95% CI = -0.13 - -0.01, p = 0.025). When adjusting for clinicodemographic variables, HIV stigma was associated with worse processing speed and global cognition at yearly follow-up visits. This finding suggests that HIV stigma precedes subsequent cognitive decline and highlights the importance of reducing stigma to improve cognitive functioning among PWH.

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HIV 耻辱感与 HIV 感染者两年认知能力下降有关。

艾滋病病毒感染者的污名化与不理想的临床结果有关，并与艾滋病病毒感染者（PWH）的认知缺陷有横断面联系。然而，HIV 耻辱感是否先于认知能力下降，抑或反之亦然，目前尚不清楚。我们研究了 303 名成年艾滋病感染者（平均年龄 50.01 (11.91) 岁；46% 为女性；67% 为非西班牙裔黑人）的缩写伯杰污名化量表得分与 NIH 工具箱认知电池测量的纵向变化之间的关系。89%的参与者表示曾遭受过艾滋病耻辱。在未经调整的分析中，HIV 耻辱感越强，每年随访时的注意力表现越差（B = -0.07，95% CI = -0.13 -0.01，P = 0.025）。在对临床人口学变量进行调整后，HIV 耻辱感与每年随访时更差的处理速度和整体认知能力有关。这一发现表明，HIV 耻辱感先于认知能力下降，并强调了减少耻辱感对改善感染者认知功能的重要性。

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来源期刊

AIDS and Behavior Multiple-

CiteScore

6.60

自引率

13.60%

发文量

382

期刊介绍： AIDS and Behavior provides an international venue for the scientific exchange of research and scholarly work on the contributing factors, prevention, consequences, social impact, and response to HIV/AIDS. This bimonthly journal publishes original peer-reviewed papers that address all areas of AIDS behavioral research including: individual, contextual, social, economic and geographic factors that facilitate HIV transmission; interventions aimed to reduce HIV transmission risks at all levels and in all contexts; mental health aspects of HIV/AIDS; medical and behavioral consequences of HIV infection - including health-related quality of life, coping, treatment and treatment adherence; and the impact of HIV infection on adults children, families, communities and societies. The journal publishes original research articles, brief research reports, and critical literature reviews. provides an international venue for the scientific exchange of research and scholarly work on the contributing factors, prevention, consequences, social impact, and response to HIV/AIDS. This bimonthly journal publishes original peer-reviewed papers that address all areas of AIDS behavioral research including: individual, contextual, social, economic and geographic factors that facilitate HIV transmission; interventions aimed to reduce HIV transmission risks at all levels and in all contexts; mental health aspects of HIV/AIDS; medical and behavioral consequences of HIV infection - including health-related quality of life, coping, treatment and treatment adherence; and the impact of HIV infection on adults children, families, communities and societies. The journal publishes original research articles, brief research reports, and critical literature reviews.5 Year Impact Factor: 2.965 (2008) Section ''SOCIAL SCIENCES, BIOMEDICAL'': Rank 5 of 29 Section ''PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH'': Rank 9 of 76