Risk of SARS-CoV-2 infection in healthcare workers with insufficient use of personal protective equipment in Denmark.

IF 1.8 4区医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Annals Of Work Exposures and Health Pub Date : 2024-10-16 DOI:10.1093/annweh/wxae075

Ane Berger Bungum, Sandra Søgaard Tøttenborg, Luise Mølenberg Begtrup, Kajsa Ugelvig Petersen, Maja Søndergård Worm, Jens Peter Bonde, Annett Dalbøge, Martin Byskov Kinnerup, Else Toft Würtz, Henrik Albert Kolstad, Vivi Schlünssen, Christine Cramer, Karin Biering, Kent Jacob Nielsen, Esben Meulengracht Flachs

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Abstract

Aim: The aim was to evaluate the role of insufficient use of personal protective equipment (PPE) in SARS-CoV-2 transmission risk for healthcare workers (HCW) during the COVID-19 pandemic.

Methods: Prospective study within the COBRA cohort, including 15,127 HCW. Daily assessment of insufficient use of PPE, defined as self-reported PPE failure or noncompliance, in relation to SARS-CoV-2 infection ascertained by polymerase chain reaction (PCR) test. Statistical analysis involved calculating incidence rate ratios with 95% confidence intervals (CI).

Results: The included HCW contributed to 780,515 risk days including 67,723 d (8.7%) with insufficient PPE use and 133 events (positive PCR test). Self-reported insufficient use of PPE was slightly associated with infection with COVID-19 in HCW, but the data were statistically consistent with parameter values ranging from a protective effect to a to a doubling in risk (IRR 1.3, 95% CI 0.8; 2.3). Sensitivity analyses restricted to high-risk departments and to a period with a sufficient supply of PPE and a fully developed testing system, respectively, confirmed these findings.

Conclusion: Insufficient use of PPE among HCW during the pandemic in Denmark was uncommon but associated with a slightly increased risk of COVID-19 among HCW. However, the findings are uncertain due to the limited number of cases and the potential for misclassification bias stemming from the self-reported nature of the exposure.

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丹麦未充分使用个人防护设备的医护人员感染 SARS-CoV-2 的风险。

目的：旨在评估在 COVID-19 大流行期间，个人防护设备（PPE）使用不足对医护人员（HCW）SARS-CoV-2 传播风险的影响：COBRA队列中的前瞻性研究，包括15127名医护人员。通过聚合酶链式反应 (PCR) 测试，对与 SARS-CoV-2 感染有关的个人防护设备使用不足（定义为自我报告的个人防护设备失效或不合规）情况进行日常评估。统计分析包括计算发病率比和 95% 的置信区间 (CI)：结果：所纳入的高危工人共造成 780,515 个风险日，其中 67,723 天（8.7%）未充分使用个人防护设备，133 个事件（PCR 检测呈阳性）。自我报告的PPE使用不足与HCW感染COVID-19略有关联，但数据在统计学上是一致的，参数值从保护作用到风险加倍（IRR 1.3，95% CI 0.8; 2.3）不等。分别针对高风险部门和个人防护设备供应充足的时期以及检测系统完善的时期进行的敏感性分析证实了这些结果：结论：在丹麦大流行期间，人机工程人员未充分使用个人防护设备的情况并不常见，但这与人机工程人员罹患 COVID-19 的风险略有增加有关。然而，由于病例数量有限，而且由于暴露的自我报告性质，可能会出现分类偏差，因此研究结果还不确定。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals Of Work Exposures and Health Medicine-Public Health, Environmental and Occupational Health

CiteScore

4.60

自引率

19.20%

发文量

期刊介绍： About the Journal Annals of Work Exposures and Health is dedicated to presenting advances in exposure science supporting the recognition, quantification, and control of exposures at work, and epidemiological studies on their effects on human health and well-being. A key question we apply to submission is, "Is this paper going to help readers better understand, quantify, and control conditions at work that adversely or positively affect health and well-being?" We are interested in high quality scientific research addressing: the quantification of work exposures, including chemical, biological, physical, biomechanical, and psychosocial, and the elements of work organization giving rise to such exposures; the relationship between these exposures and the acute and chronic health consequences for those exposed and their families and communities; populations at special risk of work-related exposures including women, under-represented minorities, immigrants, and other vulnerable groups such as temporary, contingent and informal sector workers; the effectiveness of interventions addressing exposure and risk including production technologies, work process engineering, and personal protective systems; policies and management approaches to reduce risk and improve health and well-being among workers, their families or communities; methodologies and mechanisms that underlie the quantification and/or control of exposure and risk. There is heavy pressure on space in the journal, and the above interests mean that we do not usually publish papers that simply report local conditions without generalizable results. We are also unlikely to publish reports on human health and well-being without information on the work exposure characteristics giving rise to the effects. We particularly welcome contributions from scientists based in, or addressing conditions in, developing economies that fall within the above scope.