Slight and hidden hearing loss in young rats is associated with impaired recognition memory and reduced myelination in the corpus callosum.

IF 1.6 4区 医学 Q3 BEHAVIORAL SCIENCES Behavioral neuroscience Pub Date : 2024-10-10 DOI:10.1037/bne0000601
Joëlle D Jagersma, Marleen Bakker, Jocelien D A Olivier, Sonja J Pyott
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Abstract

Slight and hidden hearing loss in children have been linked to cognitive and social difficulties, and yet the neurobiological mechanisms behind these issues remain poorly understood. Most animal models focus on severe hearing loss, leaving the effects of hidden or slight hearing loss largely unexplored. To uncover the neural mechanisms connecting slight/hidden hearing loss to cognitive and social challenges, we induced hearing loss in young (4-week-old) Wistar rats through noise exposure. We then examined cognitive function (object recognition test) and social behavior (juvenile play behavior and social interaction). Changes in brain anatomy were assessed using cortical thickness and hippocampal size measurements, while (immuno)histochemical staining investigated neuronal circuitry maturation (myelin basic protein, parvalbumin, and perineuronal nets) and neurogenesis (doublecortin). Noise-exposed rats displayed slight high-frequency hearing loss (around 20 dB) and hidden hearing loss at other tested frequencies. This slight/hidden hearing loss was associated with impaired object recognition but did not alter social behavior. Slight/hidden hearing loss was associated with reduced myelin basic protein expression in the corpus callosum but no other alterations in cortical thickness, hippocampal size, or other markers of maturation and neurogenesis were found. These findings show that even slight/hidden hearing loss can lead to subtle brain alterations tied to cognitive deficits. This study emphasizes the need for further research to fully understand the brain changes associated with slight/hidden hearing loss and to pinpoint the mechanisms connecting these changes to behavioral deficits. This information is crucial to develop interventions to prevent the cognitive and social consequences of hearing loss. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

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幼鼠轻微的隐性听力损失与识别记忆受损和胼胝体髓鞘化减少有关。
儿童的轻微和隐性听力损失与认知和社交障碍有关,但人们对这些问题背后的神经生物学机制仍然知之甚少。大多数动物模型关注的是重度听力损失,而对隐性或轻度听力损失的影响基本上没有进行研究。为了揭示轻微/隐性听力损失与认知和社交障碍之间的神经机制,我们通过噪音暴露诱导幼年(4 周大)Wistar 大鼠出现听力损失。然后,我们检测了认知功能(物体识别测试)和社会行为(幼年游戏行为和社会互动)。通过测量皮层厚度和海马体大小来评估大脑解剖结构的变化,同时通过(免疫)组织化学染色来研究神经元回路的成熟(髓鞘碱性蛋白、副神经胶质蛋白和神经元周围网)和神经发生(双皮质素)。暴露于噪声的大鼠表现出轻微的高频听力损失(约 20 dB)和其他测试频率的隐性听力损失。这种轻微/隐性听力损失与物体识别能力受损有关,但不会改变社交行为。轻微/隐性听力损失与胼胝体中髓鞘碱性蛋白表达减少有关,但没有发现皮质厚度、海马大小或其他成熟和神经发生标志物的其他改变。这些研究结果表明,即使是轻微/隐性听力损失也会导致与认知障碍相关的微妙大脑改变。这项研究强调了进一步研究的必要性,以充分了解与轻微/隐性听力损失相关的大脑变化,并确定这些变化与行为缺陷之间的关联机制。这些信息对于制定干预措施以预防听力损失造成的认知和社会后果至关重要。(PsycInfo Database Record (c) 2024 APA,保留所有权利)。
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来源期刊
Behavioral neuroscience
Behavioral neuroscience 医学-行为科学
CiteScore
3.40
自引率
0.00%
发文量
51
审稿时长
6-12 weeks
期刊介绍: Behavioral Neuroscience publishes original research articles as well as reviews in the broad field of the neural bases of behavior.
期刊最新文献
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