Individual and joint association of Life's Essential 8 metrics with pre-sarcopenia among U.S. adults.

IF 2.4 3区医学 Q2 ORTHOPEDICS BMC Musculoskeletal Disorders Pub Date : 2024-10-19 DOI:10.1186/s12891-024-07911-2

Mao-Sen Lin, Zhao-Rong Lin, Xiao-Qi Guo, Hui-Zhong Lin, Ming-Fang Ye

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Abstract

Background: In recent times, the American Heart Association has updated its approach to evaluating cardiovascular health (CVH) by replacing the previous "Life's Simple 7" with the more demanding "Life's Essential 8" (LE8). However, the impact of enhancing CVH on reducing the risk of pre-sarcopenia and the association of LE8 metrics with pre-sarcopenia remain unexplored.

Methods: LE8 score was calculated among 9857 participants. Multivariable logistic regression was utilized to investigate the associations between LE8 and pre-sarcopenia. Additionally, the weighted quantile sum (WQS) model was employed to determine the combined and individual impact of LE8 metrics on pre-sarcopenia. To assess the indirect effects of peripheral immune responses on the relationships between cardiovascular health and pre-sarcopenia, mediation analyses were performed.

Results: In this study, 827 participants had pre-sarcopenia. After accounting for potential confounding factors, the group with excellent cardiovascular health demonstrated an 83% lower risk of pre-sarcopenia compared to the poor cardiovascular health group (OR: 0.17, 95% CI: 0.11-0.27) and a 33% decreased risk of pre-sarcopenia for each 10-point increase in LE8 score (OR: 0.67, 95% CI: 0.62-0.73). Body mass index (BMI) and physical activity (PA) were the critical contributors that decreased the prevalence of pre-sarcopenia in the obese and non-obese populations, respectively.

Conclusions: A negative association was found between LE8 score and pre-sarcopenia prevalence. Body mass index and physical activity are the primary contributors to the obese and non-obese populations, respectively.

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美国成年人 "生命必备 8 项指标 "与 "前期肌肉疏松症 "的个体及联合关联。

背景：近来，美国心脏协会更新了评估心血管健康（CVH）的方法，用要求更高的 "生命必需8项"（LE8）取代了之前的 "生命简单7项"。然而，提高心血管健康水平对降低先天性肌肉疏松症风险的影响，以及 LE8 指标与先天性肌肉疏松症之间的关联仍有待研究：方法：计算了 9857 名参与者的 LE8 分数。方法：在 9857 名参与者中计算出 LE8 分数，利用多变量逻辑回归研究 LE8 与肌肉疏松症前期之间的关联。此外，还采用了加权量化总和（WQS）模型来确定 LE8 指标对肌肉疏松症前期的综合和单独影响。为了评估外周免疫反应对心血管健康与肌肉疏松症前期之间关系的间接影响，研究人员进行了中介分析：在这项研究中，有 827 人患有肌肉疏松症前期。在考虑了潜在的混杂因素后，与心血管健康状况较差的组别相比，心血管健康状况良好的组别患前肌肉疏松症的风险降低了 83%（OR：0.17，95% CI：0.11-0.27），LE8 分数每增加 10 分，患前肌肉疏松症的风险降低 33%（OR：0.67，95% CI：0.62-0.73）。体重指数（BMI）和体力活动（PA）分别是降低肥胖人群和非肥胖人群肌肉疏松症患病率的关键因素：结论：LE8 评分与肌肉疏松症患病率呈负相关。体重指数和体力活动分别是肥胖和非肥胖人群的主要因素。

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来源期刊

BMC Musculoskeletal Disorders 医学-风湿病学

CiteScore

3.80

自引率

8.70%

发文量

1017

审稿时长

3-6 weeks

期刊介绍： BMC Musculoskeletal Disorders is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of musculoskeletal disorders, as well as related molecular genetics, pathophysiology, and epidemiology. The scope of the Journal covers research into rheumatic diseases where the primary focus relates specifically to a component(s) of the musculoskeletal system.