Altered metabolic profiles in male offspring conceived from intracytoplasmic sperm injection.

IF 7 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL BMC Medicine Pub Date : 2024-10-14 DOI:10.1186/s12916-024-03654-y
Bingqian Zhang, Miaomiao Ban, Xiaojing Chen, Jingmei Hu, Linlin Cui, Zi-Jiang Chen
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引用次数: 0

Abstract

Background: While most research has focused on the association between intracytoplasmic sperm injection (ICSI) and neurodevelopmental disorders in children, relatively little attention has been given to its metabolic effects. Previous studies have reported that low serum lipid levels are associated with mental health problems. Our objective was to analyze the impact of ICSI on metabolic alterations compared to their in vitro fertilization (IVF) counterparts in male offspring, as well as its interaction with paternal overweight/obesity.

Methods: We recruited families between January 2006 and December 2017 at the Center for Reproductive Medicine, Shandong University, China. Prospective data of offspring were obtained for body mass index (BMI), blood pressure, glucose, and lipid profile in their 0-11 years old. Linear mixed models were utilized to compute the mean difference and 95% confidence intervals (CI).

Results: A total of 14,196 offspring visits were identified. In offspring aged 4-11 years, ICSI-conceived offspring exhibited significantly lower fasting glucose z-scores, total cholesterol z-scores, and low-density lipoprotein cholesterol (LDL-C) z-scores compared with their IVF counterparts (fasting glucose z-score: adjusted mean difference: - 0.13, 95% CI: - 0.23 to - 0.03; total cholesterol z-score: adjusted mean difference: - 0.13, 95% CI: - 0.23 to - 0.02; LDL-C z-score: adjusted mean difference: - 0.12, 95% CI: - 0.22 to - 0.01). Paternal overweight/obesity significantly influenced the relationship between ICSI and metabolic changes in offspring. In offspring born from fathers with overweight/obesity, ICSI-conceived offspring displayed significantly lower fasting glucose and total cholesterol z-scores than their IVF controls (fasting glucose z-score: adjusted mean difference: - 0.20, 95% CI: - 0.32 to - 0.08; total cholesterol z-score: adjusted mean difference: - 0.15, 95% CI: - 0.27 to - 0.02). In offspring born to fathers with normal weight, ICSI-conceived offspring showed significantly lower systolic blood pressure z-scores compared to those conceived via the IVF procedures (adjusted mean difference: - 0.21, 95% CI: - 0.37 to - 0.05).

Conclusions: The findings of this study suggested that ICSI was associated with altered glucose and lipid profiles compared to their IVF controls, characterized by lower fasting glucose z-scores, total cholesterol z-scores, and LDL-C z-scores. Encouraging fathers to reduce their body weight could potentially improve the metabolic health of their ICSI-conceived children.

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卵胞浆内单精子注射孕育的雄性后代的代谢特征发生变化。
背景:虽然大多数研究都集中在卵胞浆内单精子显微注射(ICSI)与儿童神经发育障碍之间的关系上,但对其代谢影响的关注相对较少。以往的研究报告显示,血清脂质水平低与精神健康问题有关。我们的目的是分析与体外受精(IVF)相比,卵胞浆内单精子显微注射对男性后代代谢改变的影响,以及它与父亲超重/肥胖的相互作用:2006年1月至2017年12月期间,我们在中国山东大学生殖医学中心招募了一些家庭。方法:我们于 2006 年 1 月至 2017 年 12 月期间在中国山东大学生殖医学中心招募了一些家庭,并获得了其 0-11 岁后代的体重指数(BMI)、血压、血糖和血脂的前瞻性数据。采用线性混合模型计算平均差异和 95% 置信区间 (CI):结果:共确定了 14196 次后代访问。在 4-11 岁的后代中,ICSI 所怀后代的空腹血糖 z-分数、总胆固醇 z-分数和低密度脂蛋白胆固醇(LDL-C)z-分数均显著低于 IVF 所怀后代(空腹血糖 z-分数:调整后均值差异为 0.13,95% CI):- 0.13,95% CI:- 0.23 至 - 0.03;总胆固醇 z-score:调整后平均差异:0.13,95% CI:- 0.23 至 - 0.03:- 0.13, 95% CI: - 0.23 to - 0.02; LDL-C z-score: adjusted mean difference:- 0.12,95% CI:- 0.22 至 - 0.01)。父亲超重/肥胖会显著影响 ICSI 与后代代谢变化之间的关系。在父亲超重/肥胖的后代中,ICSI 所怀后代的空腹血糖和总胆固醇 Z 值明显低于 IVF 对照组(空腹血糖 Z 值:调整后的平均差:0.20,95% CI:- 0.22 至 - 0.01):- 0.20, 95% CI: - 0.32 to - 0.08; 总胆固醇 z-score:调整后的平均差异:- 0.15,95% CI:- 0.27 至 - 0.02)。在体重正常的父亲所生的后代中,与通过试管婴儿程序受孕的后代相比,ICSI 受孕的后代收缩压 z 值明显较低(调整后平均差异:- 0.21,95% CI:- 0.37 至 - 0.05):本研究结果表明,与体外受精对照组相比,卵胞浆内单精子显微注射与血糖和血脂状况的改变有关,其特点是空腹血糖 z 值、总胆固醇 z 值和低密度脂蛋白胆固醇 z 值较低。鼓励父亲减轻体重有可能改善他们的 ICSI 受孕子女的代谢健康。
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来源期刊
BMC Medicine
BMC Medicine 医学-医学:内科
CiteScore
13.10
自引率
1.10%
发文量
435
审稿时长
4-8 weeks
期刊介绍: BMC Medicine is an open access, transparent peer-reviewed general medical journal. It is the flagship journal of the BMC series and publishes outstanding and influential research in various areas including clinical practice, translational medicine, medical and health advances, public health, global health, policy, and general topics of interest to the biomedical and sociomedical professional communities. In addition to research articles, the journal also publishes stimulating debates, reviews, unique forum articles, and concise tutorials. All articles published in BMC Medicine are included in various databases such as Biological Abstracts, BIOSIS, CAS, Citebase, Current contents, DOAJ, Embase, MEDLINE, PubMed, Science Citation Index Expanded, OAIster, SCImago, Scopus, SOCOLAR, and Zetoc.
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