Effect of Cannabidiol (CBD), a cannabis plant derivative, against Candida albicans growth and biofilm formation.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-10-17 DOI:10.1139/cjm-2024-0034

Maryam Bahraminia, Shujun Cui, Ze Zhang, Abdelhabib Semlali, Étienne Le Roux, Kelly-Anne Giroux, Camille Lajoie, François Béland, Mahmoud Rouabhia

{"title":"Effect of Cannabidiol (CBD), a cannabis plant derivative, against Candida albicans growth and biofilm formation.","authors":"Maryam Bahraminia, Shujun Cui, Ze Zhang, Abdelhabib Semlali, Étienne Le Roux, Kelly-Anne Giroux, Camille Lajoie, François Béland, Mahmoud Rouabhia","doi":"10.1139/cjm-2024-0034","DOIUrl":null,"url":null,"abstract":"<p><p>This study aimed to evaluate the antifungal activities of cannabidiol (CBD) against C. albicans. Yeast cells were treated once or twice with different concentrations (from 0 to 20 mg/ml) of CBD, showing a significant (p < 0.05) decreased the growth of C. albicans, with cell concentrations ranging from 5.1 × 106 cell/mL in the control to 1.8 × 106 cell/mL after one exposure to 20 µg/mL CBD. This growth reduction was greater after two exposures to CBD. After two exposures to 20 µg/mL CBD, the cell concentration was only 1.1 × 106 cell/mL. Such a growth decrease in C. albicans was confirmed by a reduced number of CFUs and a lower MTT value compared to the control. The growth inhibition was supported by a significant (p < 0.001) decrease in the yeast-to-hyphae transition, ranging from 20 ± 0.2% in the control to 2 ± 0.5% after exposure to 20 µg/mL CBD. Biofilm formation was also significantly reduced following CBD exposure. CBD at 10 and 20 µg/mL promoted the death of C. albicans through an apoptosis/necrotic pathway. Altogether, our results suggest the possible use of CBD, a cannabis derivative, to control C. albicans infection, including oral candidiasis.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1139/cjm-2024-0034","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

Abstract

This study aimed to evaluate the antifungal activities of cannabidiol (CBD) against C. albicans. Yeast cells were treated once or twice with different concentrations (from 0 to 20 mg/ml) of CBD, showing a significant (p < 0.05) decreased the growth of C. albicans, with cell concentrations ranging from 5.1 × 106 cell/mL in the control to 1.8 × 106 cell/mL after one exposure to 20 µg/mL CBD. This growth reduction was greater after two exposures to CBD. After two exposures to 20 µg/mL CBD, the cell concentration was only 1.1 × 106 cell/mL. Such a growth decrease in C. albicans was confirmed by a reduced number of CFUs and a lower MTT value compared to the control. The growth inhibition was supported by a significant (p < 0.001) decrease in the yeast-to-hyphae transition, ranging from 20 ± 0.2% in the control to 2 ± 0.5% after exposure to 20 µg/mL CBD. Biofilm formation was also significantly reduced following CBD exposure. CBD at 10 and 20 µg/mL promoted the death of C. albicans through an apoptosis/necrotic pathway. Altogether, our results suggest the possible use of CBD, a cannabis derivative, to control C. albicans infection, including oral candidiasis.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

大麻二酚（CBD）（一种大麻植物衍生物）对白色念珠菌生长和生物膜形成的影响。

本研究旨在评估大麻二酚（CBD）对白僵菌的抗真菌活性。用不同浓度（0 至 20 毫克/毫升）的大麻二酚处理酵母细胞一次或两次后，白僵菌的生长显著下降（p < 0.05），细胞浓度从对照组的 5.1 × 106 个/毫升下降到接触 20 微克/毫升大麻二酚后的 1.8 × 106 个/毫升。在两次接触 CBD 后，生长减少的幅度更大。两次接触 20 µg/mL CBD 后，细胞浓度仅为 1.1 × 106 cells/mL。与对照组相比，白僵菌的生长减少得到了 CFU 数量减少和 MTT 值降低的证实。酵母到菌丝的转化率显著下降（p < 0.001），从对照组的 20 ± 0.2% 降至接触 20 µg/mL CBD 后的 2 ± 0.5%，这也证实了生长抑制作用。暴露于 CBD 后，生物膜的形成也明显减少。浓度为 10 和 20 µg/mL 的 CBD 可通过凋亡/坏死途径促进白僵菌的死亡。总之，我们的研究结果表明，大麻衍生物 CBD 可用于控制白僵菌感染，包括口腔念珠菌病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.

期刊最新文献

Management of Cholesteatoma: Hearing Rehabilitation. Congenital Cholesteatoma. Evaluation of Cholesteatoma. Management of Cholesteatoma: Extension Beyond Middle Ear/Mastoid. Recidivism and Recurrence.