Changes in PEDF, MMP-2, and TGF-β2 levels in the aqueous humor of cataract patients and their correlation with disease severity.

IF 2.2 4区医学 Q2 MEDICINE, GENERAL & INTERNAL Clinics Pub Date : 2024-10-15 eCollection Date: 2024-01-01 DOI:10.1016/j.clinsp.2024.100402

Yong Feng Lin, Jin Xia Xie, Xiao Luan Chen

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Abstract

Objective: To explore the changes of Pigment Epithelium-Derived Factor (PEDF), Matrix Metalloproteinase-2 (MMP-2), and Transforming Growth Factor-β2 (TGF-β2) levels in the aqueous humor of cataract patients and their correlation with disease severity.

Methods: 93 cataract patients and 56 healthy subjects were study objects. PEDF, MMP-2, and TGF-β2 levels of aqueous humor were compared, and the correlation between each index and Lens Opacity Classification System (LOCS) III classification was analyzed. ROC curve was used to analyze the evaluation value of the combined detection of each index on cataract development, and logistic regression to analyze the influence of the changes of each index on cataract development.

Results: PEDF levels were lower and MMP-2 and TGF-β2 levels were higher in the aqueous humor of cataract patients than in healthy subjects. PEDF levels in the aqueous humor were negatively correlated with LOCS III classification, while MMP-2 and TGF-β2 levels were positively correlated with LOCS III classification. The AUC value of combined detection was higher than that of PEDF, MMP-2, and TGF-β2 in the aqueous humor alone. MMP-2 ≥ 15.13 pg/mL, TGF-β2 ≥ 385.91 pg/mL and PEDF < 198.85 ng/mL were risk factors for cataract development.

Conclusion: The changes in PEDF, MMP-2, and TGF-β2 levels in the aqueous humor of cataract patients are related to LOCS III classification. The combined detection is valuable in evaluating cataract development.

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白内障患者房水中 PEDF、MMP-2 和 TGF-β2 水平的变化及其与疾病严重程度的相关性。

目的方法：以93例白内障患者和56例健康受试者为研究对象，探讨白内障患者房水中色素上皮生成因子（PEDF）、基质金属蛋白酶-2（MMP-2）和转化生长因子-β2（TGF-β2）水平的变化及其与疾病严重程度的相关性。方法：以 93 例白内障患者和 56 例健康受试者为研究对象，比较白内障患者房水中 PEDF、MMP-2 和 TGF-β2 的水平，并分析各指标与晶状体混浊分级系统（LOCS）III 分级之间的相关性。采用ROC曲线分析各指标综合检测对白内障发展的评估价值，并采用Logistic回归分析各指标变化对白内障发展的影响：结果：与健康人相比，白内障患者房水中PEDF水平较低，MMP-2和TGF-β2水平较高。房水中的 PEDF 水平与 LOCS III 分级呈负相关，而 MMP-2 和 TGF-β2 水平与 LOCS III 分级呈正相关。联合检测的 AUC 值高于单独检测眼房水中 PEDF、MMP-2 和 TGF-β2 的 AUC 值。MMP-2≥15.13 pg/mL、TGF-β2≥385.91 pg/mL和PEDF<198.85 ng/mL是白内障发生的危险因素：白内障患者房水中 PEDF、MMP-2 和 TGF-β2 水平的变化与 LOCS III 分级有关。联合检测对评估白内障的发展很有价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinics 医学-医学：内科

CiteScore

4.10

自引率

3.70%

发文量

129

审稿时长

52 days

期刊介绍： CLINICS is an electronic journal that publishes peer-reviewed articles in continuous flow, of interest to clinicians and researchers in the medical sciences. CLINICS complies with the policies of funding agencies which request or require deposition of the published articles that they fund into publicly available databases. CLINICS supports the position of the International Committee of Medical Journal Editors (ICMJE) on trial registration.