Iontophoresis and electroporation-assisted microneedles: advancements and therapeutic potentials in transdermal drug delivery.

IF 5.7 3区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Drug Delivery and Translational Research Pub Date : 2024-10-21 DOI:10.1007/s13346-024-01722-7

Mehrnaz Abbasi, Braeden Heath

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Abstract

Transdermal drug delivery (TDD) using electrically assisted microneedle (MN) systems has emerged as a promising alternative to traditional drug administration routes. This review explores recent advancements in this technology across various therapeutic applications. Integrating iontophoresis (IP) and electroporation (EP) with MN technology has shown significant potential in improving treatment outcomes for various conditions. Studies demonstrate their effectiveness in enhancing vaccine and DNA delivery, improving diabetes management, and increasing efficacy in dermatological applications. The technology has also exhibited promise in delivering nonsteroidal anti-inflammatory drugs (NSAIDs), treating multiple sclerosis, and advancing obesity and cancer therapy. These systems offer improved drug permeation, targeted delivery, and enhanced therapeutic effects. While challenges remain, including safety concerns and technological limitations, ongoing research focuses on optimizing these systems for broader clinical applications. The future of electrically assisted MN technologies in TDD appears promising, with potential advancements in personalized medicine, smart monitoring systems, and expanded therapeutic applications.

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离子渗透和电穿孔辅助微针：透皮给药的进步和治疗潜力。

使用电辅助微针（MN）系统进行透皮给药（TDD）已成为替代传统给药途径的一种前景广阔的方法。本综述探讨了该技术在各种治疗应用中的最新进展。将离子渗透（IP）和电穿孔（EP）与微针技术相结合，在改善各种疾病的治疗效果方面显示出巨大的潜力。研究表明，它们在加强疫苗和 DNA 输送、改善糖尿病管理和提高皮肤病应用疗效方面非常有效。该技术在递送非甾体抗炎药（NSAIDs）、治疗多发性硬化症以及促进肥胖症和癌症治疗方面也显示出前景。这些系统可改善药物渗透、定向递送和增强治疗效果。尽管挑战依然存在，包括安全问题和技术限制，但目前的研究重点是优化这些系统，使其应用于更广泛的临床领域。TDD 中的电辅助 MN 技术前景广阔，有望在个性化医疗、智能监控系统和扩大治疗应用方面取得进展。

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来源期刊

Drug Delivery and Translational Research MEDICINE, RESEARCH & EXPERIMENTALPHARMACOL-PHARMACOLOGY & PHARMACY

CiteScore

11.70

自引率

1.90%

发文量

160

期刊介绍： The journal provides a unique forum for scientific publication of high-quality research that is exclusively focused on translational aspects of drug delivery. Rationally developed, effective delivery systems can potentially affect clinical outcome in different disease conditions. Research focused on the following areas of translational drug delivery research will be considered for publication in the journal. Designing and developing novel drug delivery systems, with a focus on their application to disease conditions; Preclinical and clinical data related to drug delivery systems; Drug distribution, pharmacokinetics, clearance, with drug delivery systems as compared to traditional dosing to demonstrate beneficial outcomes Short-term and long-term biocompatibility of drug delivery systems, host response; Biomaterials with growth factors for stem-cell differentiation in regenerative medicine and tissue engineering; Image-guided drug therapy, Nanomedicine; Devices for drug delivery and drug/device combination products. In addition to original full-length papers, communications, and reviews, the journal includes editorials, reports of future meetings, research highlights, and announcements pertaining to the activities of the Controlled Release Society.