Nattokinase as an adjuvant therapeutic strategy for non-communicable diseases: a review of fibrinolytic, antithrombotic, anti-inflammatory, and antioxidant effects.

IF 1.8 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Expert Review of Cardiovascular Therapy Pub Date : 2024-10-01 Epub Date: 2024-10-15 DOI:10.1080/14779072.2024.2416663
Mariana Granito, Livia Alvarenga, Marcia Ribeiro, Priscila Carvalhosa, Thaysi Andrade, Claudio Tinoco Mesquita, Milena Barcza Stockler-Pinto, Denise Mafra, Ludmila Fmf Cardozo
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Abstract

Introduction: Nattokinase (NK) is the primary ingredient of natto, a traditional Asian food made from fermented soybean by Bacillus subtilis natto. Studies have shown that natto reduces the risk of cardiovascular disease (CVD) mortality due to its fibrinolytic and antithrombotic properties. A new field of studies also demonstrates that NK can mitigate molecular pathways related to inflammation and oxidative stress and can be considered an adjuvant strategy for use in many non-communicable diseases (NCDs). This paper is a narrative review of the literature. A search was conducted in PubMed and ScienceDirect up to July 2024.

Areas covered: This review discusses the possible effects of NK on mitigating the common complications of NCDs, such as inflammation and oxidative stress. In addition, it provides an update on the most addressed areas related to NK's fibrinolytic and antithrombotic activities.

Expert opinion: Due to the fibrinolytic and antithrombotic activity of nattokinase, and more recently added to the anti-inflammatory and antioxidant effects, this enzyme can be used as a new adjuvant therapeutic strategy to mitigate inflammation and oxidative stress in NCDs, including CVD.

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纳豆激酶作为非传染性疾病的辅助治疗策略:纤维蛋白溶解、抗血栓、抗炎和抗氧化作用综述。
简介纳豆是一种由纳豆芽孢杆菌发酵大豆制成的亚洲传统食品,纳豆激酶(NK)是纳豆的主要成分。研究表明,纳豆具有纤维蛋白溶解和抗血栓形成的特性,可降低心血管疾病(CVD)的死亡风险。一个新的研究领域还表明,纳豆可以缓解与炎症和氧化应激有关的分子通路,可被视为用于许多非传染性疾病(NCDs)的辅助策略。本文是一篇叙述性文献综述。在 PubMed 和 ScienceDirect 上进行了搜索,搜索结果截止到 2024 年 7 月:本综述讨论了 NK 对减轻非传染性疾病常见并发症(如炎症和氧化应激)可能产生的影响。此外,它还提供了与 NK 的纤维蛋白溶解和抗血栓活性相关的最新研究进展:由于纳豆激酶具有纤维蛋白溶解和抗血栓活性,最近又增加了抗炎和抗氧化作用,因此这种酶可用作一种新的辅助治疗策略,以减轻包括心血管疾病在内的非传染性疾病中的炎症和氧化应激。
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来源期刊
Expert Review of Cardiovascular Therapy
Expert Review of Cardiovascular Therapy CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
3.70
自引率
0.00%
发文量
82
期刊介绍: Expert Review of Cardiovascular Therapy (ISSN 1477-9072) provides expert reviews on the clinical applications of new medicines, therapeutic agents and diagnostics in cardiovascular disease. Coverage includes drug therapy, heart disease, vascular disorders, hypertension, cholesterol in cardiovascular disease, heart disease, stroke, heart failure and cardiovascular surgery. The Expert Review format is unique. Each review provides a complete overview of current thinking in a key area of research or clinical practice.
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