Winnie Chemutai Sum , Sherif S. Ebada , Jackson M. Muema , Harald Kellner , Attila Mándi , Tibor Kurtán , Marc Stadler
{"title":"Hermansones A and B: Bioactive naphthazarin congeners from the European crust fungus Hermanssonia centrifuga","authors":"Winnie Chemutai Sum , Sherif S. Ebada , Jackson M. Muema , Harald Kellner , Attila Mándi , Tibor Kurtán , Marc Stadler","doi":"10.1016/j.fitote.2024.106261","DOIUrl":null,"url":null,"abstract":"<div><div>Two previously undescribed naphthazarins named hermansones A (<strong>1</strong>) and B (<strong>2</strong>), were isolated from the wood-decaying basidiomycete <em>Hermanssonia centrifuga</em>. The study presents the first report of natural products from the species. The structures of the secondary metabolites were elucidated through NMR spectroscopy and mass spectrometry. The absolute configuration of compound <strong>1</strong> was elucidated using TDDFT-ECD calculations. Hermansone B (<strong>2</strong>) demonstrated moderate inhibitory effects against Chikungunya virus at IC<sub>50</sub> of 55.97 μM, without inducing notable cytotoxicity.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"179 ","pages":"Article 106261"},"PeriodicalIF":2.5000,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Fitoterapia","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0367326X24004441","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
Two previously undescribed naphthazarins named hermansones A (1) and B (2), were isolated from the wood-decaying basidiomycete Hermanssonia centrifuga. The study presents the first report of natural products from the species. The structures of the secondary metabolites were elucidated through NMR spectroscopy and mass spectrometry. The absolute configuration of compound 1 was elucidated using TDDFT-ECD calculations. Hermansone B (2) demonstrated moderate inhibitory effects against Chikungunya virus at IC50 of 55.97 μM, without inducing notable cytotoxicity.
期刊介绍：
Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas:
1. Characterization of active ingredients of medicinal plants
2. Development of standardization method for bioactive plant extracts and natural products
3. Identification of bioactivity in plant extracts
4. Identification of targets and mechanism of activity of plant extracts
5. Production and genomic characterization of medicinal plants biomass
6. Chemistry and biochemistry of bioactive natural products of plant origin
7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
