Obesity may impair response to ovarian stimulation. A retrospective observational study on oocyte quality.

IF 4.6 2区生物学 Q2 CELL BIOLOGY Frontiers in Cell and Developmental Biology Pub Date : 2024-09-30 eCollection Date: 2024-01-01 DOI:10.3389/fcell.2024.1461132

Irene Iavarone, Daniela Mele, Francesca Caprio, Giada Andreoli, Maria Giovanna Vastarella, Pasquale de Franciscis, Carlo Ronsini

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Abstract

Background: Ovulatory dysfunction is more common in women with obesity. Body fat distribution is also crucial because anovulatory women have a greater waist circumference and more abdominal fat than ovulatory women of similar BMI. The primary aim of the present study is to determine whether there is a relationship between BMI and reproductive characteristics, including hormonal values, antral follicle count (AFC), endometrial assessment at transvaginal ultrasound evaluation (TVUS) during controlled ovarian stimulation (COS), and oocyte retrieval after Ovum Pick-Up (OPU).

Methods: Data from a cohort of 183 patients were analyzed and divided into three groups based on weight status: normal weight, overweight, and obesity. Evaluated reproductive characteristics included: age, basal values of follicle-stimulating hormone (FSH), luteinizing hormone (LH), 17-beta-estradiol (E2), thyroid stimulating hormone (TSH), anti-müllerian hormone (AMH), antral-follicle-count (AFC), duration of COS, E2, and progesterone at the last monitoring, TVUS endometrial thickness at the last monitoring before OPU, FOI after OPU. Additionally, the number of meiosis II oocytes retrieved (MII), the total dose of FSH administered, the ratio between MII and total FSH administered, and OSI were registered.

Results: AMH levels were significantly lower in obese patients compared to normal weight and overweight women (1.05 IQR 1.20, 1.58 IQR 2.16, 1.32 IQR 1.38, respectively, p-value = 0.032). When looking at the MII/FSH ratio, the normal weight group showed a median value of 3.3 with an IQR of 4.0, the overweight group showed a median value of 2.3 with an IQR of 1.9, and the obese group had a median value of 2.6 with an IQR of 2.8. Those data were statistically significant (p-value = 0.049).

Conclusion: These results emphasize the importance of considering weight status in fertility assessment and treatment planning.

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肥胖可能会影响卵巢刺激反应。一项关于卵母细胞质量的回顾性观察研究。

背景：排卵功能障碍在肥胖女性中更为常见。身体脂肪分布也至关重要，因为与体重指数相似的排卵期妇女相比，无排卵妇女的腰围更大，腹部脂肪更多。本研究的主要目的是确定体重指数与生殖特征之间是否存在关系，包括激素值、前卵泡计数（AFC）、控制性卵巢刺激（COS）期间经阴道超声评估（TVUS）的子宫内膜评估以及取卵（OPU）后的卵母细胞检索：对 183 名患者的数据进行了分析，并根据体重状况分为三组：正常体重组、超重组和肥胖组。评估的生殖特征包括：年龄、卵泡刺激素（FSH）、黄体生成素（LH）、17-beta-雌二醇（E2）、促甲状腺激素（TSH）、抗苗勒氏激素（AMH）的基础值、前卵泡数（AFC）、COS持续时间、上次监测的E2和孕酮、OPU前最后一次监测的TVUS子宫内膜厚度、OPU后的FOI。此外，还记录了减数第二次分裂取卵数（MII）、FSH总剂量、MII与FSH总剂量之比以及OSI：与正常体重和超重妇女相比，肥胖患者的 AMH 水平明显较低（分别为 1.05 IQR 1.20、1.58 IQR 2.16、1.32 IQR 1.38，P 值 = 0.032）。在观察 MII/FSH 比率时，正常体重组的中位值为 3.3，IQR 为 4.0；超重组的中位值为 2.3，IQR 为 1.9；肥胖组的中位值为 2.6，IQR 为 2.8。这些数据具有统计学意义（P 值 = 0.049）：这些结果强调了在生育评估和治疗计划中考虑体重状况的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Cell and Developmental Biology Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

9.70

自引率

3.60%

发文量

2531

审稿时长

12 weeks

期刊介绍： Frontiers in Cell and Developmental Biology is a broad-scope, interdisciplinary open-access journal, focusing on the fundamental processes of life, led by Prof Amanda Fisher and supported by a geographically diverse, high-quality editorial board. The journal welcomes submissions on a wide spectrum of cell and developmental biology, covering intracellular and extracellular dynamics, with sections focusing on signaling, adhesion, migration, cell death and survival and membrane trafficking. Additionally, the journal offers sections dedicated to the cutting edge of fundamental and translational research in molecular medicine and stem cell biology. With a collaborative, rigorous and transparent peer-review, the journal produces the highest scientific quality in both fundamental and applied research, and advanced article level metrics measure the real-time impact and influence of each publication.