Xiaolan Ouyang BS , Xixiang Tang MD , Long Peng MD , Hongxing Wu BS , Jiafu Wang BS , Zhuoshan Huang MD , Bingyuan Wu MD , Yue Li MD , Yan Lu MD , Xiaodong Zhuang MD , Yesheng Ling MD , Suhua Li MD
{"title":"Remnant cholesterol and new-onset atrial fibrillation: The Atherosclerosis Risk in Communities study","authors":"Xiaolan Ouyang BS , Xixiang Tang MD , Long Peng MD , Hongxing Wu BS , Jiafu Wang BS , Zhuoshan Huang MD , Bingyuan Wu MD , Yue Li MD , Yan Lu MD , Xiaodong Zhuang MD , Yesheng Ling MD , Suhua Li MD","doi":"10.1016/j.hrthm.2024.10.030","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>The relationship between remnant cholesterol (RC) and atrial fibrillation (AF) remains unclear.</div></div><div><h3>Objective</h3><div>The purpose of this study was to comprehensively explore the association between RC characteristics and new-onset AF.</div></div><div><h3>Methods</h3><div>Data from 5 follow-up visits of the ARIC (Atherosclerosis Risk in Communities) study were analyzed. RC were multidimensionally evaluated in 4 characteristics: baseline level, variability, cumulative exposure, and trajectory. Baseline RC was obtained from the initial visit (V1), and new-onset AF was monitored in V2 to V5 (cohort 1, n = 14,450). RC variability, cumulative RC, and RC trajectory were calculated by RC values gathered from V1 to V3, and new-onset AF was monitored in V4 and V5 (cohort 2, n = 11,012). Participants were divided into 4 groups based on quartiles or trajectories. Cox proportional hazards analyses were used to investigate the relationship between RC characteristics and AF.</div></div><div><h3>Results</h3><div>Following median follow-up of 22.39 years in cohort 1 and 16.71 years in cohort 2, a total of 1993 AF events in cohort 1 and 1571 in cohort 2 were identified. Participants with the highest quartile exhibited an elevated risk of new-onset AF, with the multivariable-adjusted hazard ratios of 1.16 (<em>P</em> = .039) for baseline RC and 1.30 (<em>P</em> < .001) for RC variability. Although the highest quartile of cumulative RC (<em>P</em> = .241) and the high-increasing trajectory (<em>P</em> = .210) did not demonstrate a statistically significant association with AF occurrence, they indicate a trend toward heightened risk.</div></div><div><h3>Conclusion</h3><div>Our findings reveal that higher levels of RC, particularly at baseline and in variability, are associated with an increased risk of AF.</div></div>","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":"22 9","pages":"Pages 2233-2242"},"PeriodicalIF":5.7000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Heart rhythm","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1547527124034568","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/10/19 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0
Abstract
Background
The relationship between remnant cholesterol (RC) and atrial fibrillation (AF) remains unclear.
Objective
The purpose of this study was to comprehensively explore the association between RC characteristics and new-onset AF.
Methods
Data from 5 follow-up visits of the ARIC (Atherosclerosis Risk in Communities) study were analyzed. RC were multidimensionally evaluated in 4 characteristics: baseline level, variability, cumulative exposure, and trajectory. Baseline RC was obtained from the initial visit (V1), and new-onset AF was monitored in V2 to V5 (cohort 1, n = 14,450). RC variability, cumulative RC, and RC trajectory were calculated by RC values gathered from V1 to V3, and new-onset AF was monitored in V4 and V5 (cohort 2, n = 11,012). Participants were divided into 4 groups based on quartiles or trajectories. Cox proportional hazards analyses were used to investigate the relationship between RC characteristics and AF.
Results
Following median follow-up of 22.39 years in cohort 1 and 16.71 years in cohort 2, a total of 1993 AF events in cohort 1 and 1571 in cohort 2 were identified. Participants with the highest quartile exhibited an elevated risk of new-onset AF, with the multivariable-adjusted hazard ratios of 1.16 (P = .039) for baseline RC and 1.30 (P < .001) for RC variability. Although the highest quartile of cumulative RC (P = .241) and the high-increasing trajectory (P = .210) did not demonstrate a statistically significant association with AF occurrence, they indicate a trend toward heightened risk.
Conclusion
Our findings reveal that higher levels of RC, particularly at baseline and in variability, are associated with an increased risk of AF.
期刊介绍：
HeartRhythm, the official Journal of the Heart Rhythm Society and the Cardiac Electrophysiology Society, is a unique journal for fundamental discovery and clinical applicability.
HeartRhythm integrates the entire cardiac electrophysiology (EP) community from basic and clinical academic researchers, private practitioners, engineers, allied professionals, industry, and trainees, all of whom are vital and interdependent members of our EP community.
The Heart Rhythm Society is the international leader in science, education, and advocacy for cardiac arrhythmia professionals and patients, and the primary information resource on heart rhythm disorders. Its mission is to improve the care of patients by promoting research, education, and optimal health care policies and standards.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
