Accuracy of intraoperative frozen section in surgical staging of endometrial cancer.

IF 3.4 3区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Heliyon Pub Date : 2024-10-05 eCollection Date: 2024-10-15 DOI:10.1016/j.heliyon.2024.e39027

Sevki G Gokulu, Tolgay T Ilhan, Gorkem Ulger, Ali Yildizbakan, Murside Cevikoglu-Killi, Ayse Turkmen

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Abstract

Objective: This study evaluates the role of frozen section (FS) in determining the extent of disease during surgery.

Materials and methods: This study retrospectively analyzed a cohort of patients diagnosed with endometrioid-type endometrial cancer between 2019 and 2022 who underwent surgical intervention. The frozen section (FS) results were compared with the final pathology reports, focusing on tumor grade, depth of myometrial invasion, cervical involvement, and tumor diameter.

Results: The final analysis included 187 patients. The predictive accuracy of FS in determining PS results was 85.6 % for endometrioid histology, 95.7 % for grade 3 tumors, 90.2 % for depth of myometrial invasion, 89.7 % for cervical involvement, and 95.9 % for tumor diameter. Notably, 9.8 % of cases initially classified as grade 1 intraoperatively were upgraded with the final pathology. Similarly, 6.3 % of grade II cases were upgraded, while 60.4 % were downgraded.

Conclusion: Our study highlights the effectiveness of FS as a dependable tool for assessing endometrial carcinomas and guiding surgical staging decisions. By utilizing FS, the risk of unnecessary surgeries and associated morbidity in patients can be reduced.

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术中冰冻切片对子宫内膜癌手术分期的准确性。

目的：本研究评估了冰冻切片（FS）在手术过程中确定疾病范围的作用：本研究评估了冰冻切片（FS）在手术中确定疾病范围的作用：本研究回顾性分析了2019年至2022年期间确诊为子宫内膜样型子宫内膜癌并接受手术治疗的患者队列。将冰冻切片（FS）结果与最终病理报告进行比较，重点关注肿瘤分级、子宫肌层浸润深度、宫颈受累情况和肿瘤直径：结果：最终分析包括 187 名患者。在确定 PS 结果时，FS 对子宫内膜样组织学的预测准确率为 85.6%，对 3 级肿瘤的预测准确率为 95.7%，对子宫肌层浸润深度的预测准确率为 90.2%，对宫颈受累的预测准确率为 89.7%，对肿瘤直径的预测准确率为 95.9%。值得注意的是，9.8%的术中初步分级为 1 级的病例在最终病理结果中得到了升级。同样，6.3%的II级病例得到升级，而60.4%的病例被降级：我们的研究强调了FS作为评估子宫内膜癌和指导手术分期决策的可靠工具的有效性。通过使用FS，可以降低患者进行不必要手术的风险和相关的发病率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Heliyon MULTIDISCIPLINARY SCIENCES-

CiteScore

4.50

自引率

2.50%

发文量

2793

期刊介绍： Heliyon is an all-science, open access journal that is part of the Cell Press family. Any paper reporting scientifically accurate and valuable research, which adheres to accepted ethical and scientific publishing standards, will be considered for publication. Our growing team of dedicated section editors, along with our in-house team, handle your paper and manage the publication process end-to-end, giving your research the editorial support it deserves.