Diminished ovarian reserve associates with pregnancy and birth outcomes after IVF: a retrospective cohort study.

IF 2.1 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Human Fertility Pub Date : 2024-12-01 Epub Date: 2024-10-14 DOI:10.1080/14647273.2024.2414813
Shen Can, Xiaoyan Yang, Ye He, Chao Wang, Huijuan Zou, Qingling Fan, Xiaofeng Xu, Guoqi Cai, Cao Yunxia, Peng Xiaoqing
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Abstract

Antral follicle count (AFC) and serum anti-Müllerian hormone (AMH) are currently the most sensitive and reliable markers of ovarian reserve, but the role of AFC and AMH, as prognosis markers of diminished ovarian reserve (DOR), in pregnancy outcomes after embryo transfer (ET) have been inconsistent. A retrospective cohort study was conducted in a university-affiliated hospital. A total of 4599 women who received their first IVF treatment between January 2012 and December 2019 were included. Uni- and multi-variable regression models were used to determine the association of DOR evaluated by AFC and AMH with pregnancy, number of ET cycles to pregnancy, live birth, preterm birth, and low birth weight. Among the women included, 380 (8.3%) had DOR (i.e. AFC <5 or AMH <1.2 μg/L). After adjusting for confounders, DOR determined by AFC/AMH, AFC alone and AMH alone was associated with a lower pregnancy rate (Risk ratio [RR] 0.81, 95% confidence interval [CI] 0.73-0.89). Among women who were successfully pregnant, DOR evaluated by AFC/AMH but not evaluated by AFC alone or AMH alone was associated with an increased number of ET cycles to pregnancy (Odds ratio 1.43, 95% CI 1.04-1.96). DOR was not associated with the risks of live birth, low birth weight, and preterm birth. Women with DOR may have more difficulty becoming pregnant after IVF treatment, suggesting the predictive role of DOR in pregnancy outcomes before IVF treatment.

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卵巢储备功能减退与体外受精后妊娠和分娩结果的关系:一项回顾性队列研究。
前房卵泡计数(AFC)和血清抗缪勒氏管激素(AMH)是目前卵巢储备功能最敏感、最可靠的标志物,但作为卵巢储备功能减退(DOR)的预后标志物,AFC和AMH在胚胎移植(ET)后妊娠结局中的作用并不一致。一项回顾性队列研究在一家大学附属医院进行。共纳入了 4599 名在 2012 年 1 月至 2019 年 12 月期间接受首次试管婴儿治疗的女性。研究采用单变量和多变量回归模型来确定通过AFC和AMH评估的DOR与妊娠、ET周期数到妊娠、活产、早产和低出生体重的关系。在纳入的妇女中,有 380 人(8.3%)患有 DOR(即 AFC
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来源期刊
Human Fertility
Human Fertility OBSTETRICS & GYNECOLOGY-REPRODUCTIVE BIOLOGY
CiteScore
3.30
自引率
5.30%
发文量
50
期刊介绍: Human Fertility is a leading international, multidisciplinary journal dedicated to furthering research and promoting good practice in the areas of human fertility and infertility. Topics included span the range from molecular medicine to healthcare delivery, and contributions are welcomed from professionals and academics from the spectrum of disciplines concerned with human fertility. It is published on behalf of the British Fertility Society. The journal also provides a forum for the publication of peer-reviewed articles arising out of the activities of the Association of Biomedical Andrologists, the Association of Clinical Embryologists, the Association of Irish Clinical Embryologists, the British Andrology Society, the British Infertility Counselling Association, the Irish Fertility Society and the Royal College of Nursing Fertility Nurses Group. All submissions are welcome. Articles considered include original papers, reviews, policy statements, commentaries, debates, correspondence, and reports of sessions at meetings. The journal also publishes refereed abstracts from the meetings of the constituent organizations.
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