Risk factors for postoperative complications in patients undergoing cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy: A meta-analysis and systematic review.

IF 2.5 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY International Journal of Colorectal Disease Pub Date : 2024-10-18 DOI:10.1007/s00384-024-04741-5

Dengzhuo Chen, Yongli Ma, Jinghui Li, Liang Wen, Guosheng Zhang, Chengzhi Huang, Xueqing Yao

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Abstract

Objective: Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) is one of the most effective treatments for intraperitoneal malignancies. However, current research on risk factors for postoperative complications needs to be more consistent. This study aimed to conduct a meta-analysis of the risk factors for postoperative complications in CRS + HIPEC patients.

Methods: Studies meeting the inclusion criteria were screened by searching the Embase, PubMed, Cochrane and Web of Science databases. RevMan and STATA software were used to analyze the data extracted from the included articles.

Results: A total of 15 articles with 4021 patients were included in the meta-analysis. The results revealed that sex, elevated peritoneal cancer index, prolonged duration of surgery and smoking habits were risk factors for postoperative complications in CRS + HIPEC patients. In contrast, BMI, eGFR, age, history of preoperative chemotherapy, history of preoperative surgery, and history of neoadjuvant therapy had no significant effect on postoperative complications in the CRS + HIPEC group. The effects of diabetes, hypertension, preoperative albumin level, tumor location and chemotherapy regimen on the occurrence of complications need to be further investigated.

Conclusions: We identified several risk factors for postoperative complications after CRS + HIPEC, which should help clinicians minimize the incidence of postoperative complications and make more beneficial decisions for cancer patients who need treatment.

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接受细胞减灭术联合腹腔内热化疗患者术后并发症的风险因素：荟萃分析和系统综述。

目的：腹腔镜手术（CRS）联合腹腔内热化疗（HIPEC）是治疗腹腔内恶性肿瘤最有效的方法之一。然而，目前对术后并发症风险因素的研究需要更加一致。本研究旨在对CRS + HIPEC患者术后并发症的风险因素进行荟萃分析：通过检索 Embase、PubMed、Cochrane 和 Web of Science 数据库筛选符合纳入标准的研究。使用RevMan和STATA软件分析从纳入文章中提取的数据：结果：共有 15 篇文章、4021 名患者被纳入荟萃分析。结果显示，性别、腹膜癌指数升高、手术时间过长和吸烟习惯是 CRS + HIPEC 患者术后并发症的危险因素。相比之下，BMI、eGFR、年龄、术前化疗史、术前手术史、新辅助治疗史对CRS + HIPEC组术后并发症无明显影响。糖尿病、高血压、术前白蛋白水平、肿瘤位置和化疗方案对并发症发生的影响有待进一步研究：我们发现了CRS + HIPEC术后并发症的几个风险因素，这应有助于临床医生最大限度地降低术后并发症的发生率，并为需要治疗的癌症患者做出更有利的决定。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Colorectal Disease 医学-外科

CiteScore

4.90

自引率

3.60%

发文量

206

审稿时长

3-8 weeks

期刊介绍： The International Journal of Colorectal Disease, Clinical and Molecular Gastroenterology and Surgery aims to publish novel and state-of-the-art papers which deal with the physiology and pathophysiology of diseases involving the entire gastrointestinal tract. In addition to original research articles, the following categories will be included: reviews (usually commissioned but may also be submitted), case reports, letters to the editor, and protocols on clinical studies. The journal offers its readers an interdisciplinary forum for clinical science and molecular research related to gastrointestinal disease.